Phytotherapy in endometriosis An up-to-date review
| Autor: | Ursula Catena, Maria Magliarditi, Michał Ciebiera, Zaki Sleiman, Giovanni Falzone, Luigi Della Corte, Simone Garzon, Calogero Salvaggio, Erbil Karaman, Marco Noventa |
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| Přispěvatelé: | DELLA CORTE, Luigi, Noventa, Marco, Ciebiera, Michal, Magliarditi, Maria, Sleiman, Zaki, Karaman, Erbil, Catena, Ursula, Salvaggio, Calogero, Falzone, Giovanni, Garzon, Simone |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
endometriosis
Gynecological disease medicine.drug_class Endometriosis Disease flavonoids pharmacological treatments phytochemicals phytotherapy Bioinformatics law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law medicine Animals Humans endometriosis flavonoids pharmacological treatments phytochemicals phytotherapy Medicinal plants Plants Medicinal 030219 obstetrics & reproductive medicine business.industry medicine.disease Clinical trial Treatment Outcome Complementary and alternative medicine Estrogen 030220 oncology & carcinogenesis Female Plant Preparations business Phytotherapy |
| Popis: | Endometriosis is a benign gynecological disease which symptoms can provide a severe impact on patient’s quality of life with subsequent impact on psychological well-being. Different therapeutic strategies are available to treat this disease, such as surgery, hormonal therapies, and nonsteroidal anti-inflammatory drugs. Nevertheless, the efficacy of conventional medical treatments is limited or intermittent in most of the patients due to the associated side effects. Therefore, a woman with endometriosis often search for additional and alternative options, and phytotherapy might be a promising alternative and complementary strategy. Different medicinal plants, multicomponent herbal preparations, and phytochemicals were investigated for pharmacological proprieties in endometriosis therapy. In most of the cases, the effect on endometriosis was related to phenolic compounds, such as flavonoids and phenolic acids reporting anti-inflammatory, proapoptotic, antioxidant, and immunomodulatory functions. Moreover, some phytochemicals have been related to a strong phytoestrogenic effect modulating the estrogen activity. Although promising, available evidence is based on in vitro and animal models of endometriosis with a limited number of well-performed clinical studies. There are almost none randomized control trials in this area. Therefore, properly constructed clinical trials are mandatory to achieve more conclusive results about the promising role of phytotherapy in the management of endometriosis. |
| Databáze: | OpenAIRE |
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