A natural symbiotic bacterium drives mosquito refractoriness to Plasmodium infection via secretion of an antimalarial lipase
| Autor: | Shengguo Li, Liang Bai, Zhenghui Huang, Yongmao Jiang, Jun Cao, Xishang Li, Guoding Zhu, Duoquan Wang, Marcelo Jacobs-Lorena, Lili Wang, Lubing Jiang, Wei Huang, Sibao Wang, Han Gao, Shuai Zhan |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Male China Serratia Immunology Plasmodium vivax ved/biology.organism_classification_rank.species Plasmodium falciparum Mosquito Vectors Applied Microbiology and Biotechnology Microbiology Plasmodium Article Anopheles sinensis 03 medical and health sciences Bacterial Proteins parasitic diseases Anopheles Genetics medicine Malaria Vivax Animals Humans Plasmodium berghei Symbiosis 030304 developmental biology 0303 health sciences biology 030306 microbiology ved/biology Cell Biology Lipase biology.organism_classification medicine.disease Gastrointestinal Tract Human parasite Female Malaria Symbiotic bacteria |
| Zdroj: | Nat Microbiol |
| Popis: | The stalling global progress in the fight against malaria prompts the urgent need to develop new intervention strategies. Whilst engineered symbiotic bacteria have been shown to confer mosquito resistance to parasite infection, a major challenge for field implementation is to address regulatory concerns. Here, we report the identification of a Plasmodium-blocking symbiotic bacterium, Serratia ureilytica Su_YN1, isolated from the midgut of wild Anopheles sinensis in China that inhibits malaria parasites via secretion of an antimalarial lipase. Analysis of Plasmodium vivax epidemic data indicates that local malaria cases in Tengchong (Yunnan province, China) are significantly lower than imported cases and importantly, that the local vector A. sinensis is more resistant to infection by P. vivax than A. sinensis from other regions. Analysis of the gut symbiotic bacteria of mosquitoes from Yunnan province led to the identification of S. ureilytica Su_YN1. This bacterium renders mosquitoes resistant to infection by the human parasite Plasmodium falciparum or the rodent parasite Plasmodium berghei via secretion of a lipase that selectively kills parasites at various stages. Importantly, Su_YN1 rapidly disseminates through mosquito populations by vertical and horizontal transmission, providing a potential tool for blocking malaria transmission in the field. |
| Databáze: | OpenAIRE |
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