Exposure to biomass smoke is associated with an increased expression of circulating miRNA-126 and miRNA-155 in Mexican women: a pilot study
| Autor: | Iván N. Pérez-Maldonado, Tania Ruíz-Vera, Ángeles C. Ochoa-Martínez, Sergio Zarazúa, Lucia G. Pruneda-Álvarez |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Circulating mirnas Health Toxicology and Mutagenesis Urinary system Physiology Biomass smoke Pilot Projects 010501 environmental sciences Toxicology 01 natural sciences miR-155 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Smoke microRNA Humans Medicine Cooking Risk factor Mexico 0105 earth and related environmental sciences Pharmacology Air Pollutants Inhalation Exposure Creatinine Chemical Health and Safety business.industry Public Health Environmental and Occupational Health General Medicine Wood MicroRNAs chemistry Female business 030217 neurology & neurosurgery |
| Zdroj: | Drug and Chemical Toxicology. 42:335-342 |
| ISSN: | 1525-6014 0148-0545 |
| DOI: | 10.1080/01480545.2018.1526181 |
| Popis: | Household air pollution has been associated as a risk factor for cardiovascular diseases (CVD). Therefore, the aim of this study was to assess the expression of vascular inflammation regulators miR-126 and miR-155 in plasma from women that cook with wood and women that cook with liquid petroleum gas (LPG). A cumulative index of exposure to smoke (CIES) was estimated, urinary 1-hydroxypyrene (1-OHP) levels were quantified and miRNAs expression levels were determined by quantitative real-time PCR (qRT-PCR). Biochemical clinical parameters were also evaluated. The average values for CIES and 1-OHP were 140 ± 86.8 hours-years (12.0-270 hours-years) and 0.52 ± 0.45 µmol/mol creatinine, respectively. miR-126 and miR-155 expression levels were significantly higher (p |
| Databáze: | OpenAIRE |
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