Remineralization, Regeneration, and Repair of Natural Tooth Structure: Influences on the Future of Restorative Dentistry Practice
| Autor: | Riham Fliefel, Dalia Kaisarly, Rasha Haridy, Moataz El Gezawi, Uta Christine Wölfle |
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| Rok vydání: | 2021 |
| Předmět: |
Periodontitis
3D bioprinting business.industry Regeneration (biology) 0206 medical engineering Biomedical Engineering Dentistry 02 engineering and technology Periodontium 021001 nanoscience & nanotechnology medicine.disease 020601 biomedical engineering law.invention Biomaterials stomatognathic diseases stomatognathic system law Biodegradable scaffold Medicine Periodontal fiber Natural tooth 0210 nano-technology business Restorative dentistry |
| Zdroj: | ACS biomaterials scienceengineering. 5(10) |
| ISSN: | 2373-9878 |
| Popis: | Currently, the principal strategy for the treatment of carious defects involves cavity preparations followed by the restoration of natural tooth structure with a synthetic material of inferior biomechanical and esthetic qualities and with questionable long-term clinical reliability of the interfacial bonds. Consequently, prevention and minimally invasive dentistry are considered basic approaches for the preservation of sound tooth structure. Moreover, conventional periodontal therapies do not always ensure predictable outcomes or completely restore the integrity of the periodontal ligament complex that has been lost due to periodontitis. Much effort and comprehensive research have been undertaken to mimic the natural development and biomineralization of teeth to regenerate and repair natural hard dental tissues and restore the integrity of the periodontium. Regeneration of the dentin-pulp tissue has faced several challenges, starting with the basic concerns of clinical applicability. Recent technologies and multidisciplinary approaches in tissue engineering and nanotechnology, as well as the use of modern strategies for stem cell recruitment, synthesis of effective biodegradable scaffolds, molecular signaling, gene therapy, and 3D bioprinting, have resulted in impressive outcomes that may revolutionize the practice of restorative dentistry. This Review covers the current approaches and technologies for remineralization, regeneration, and repair of natural tooth structure. |
| Databáze: | OpenAIRE |
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