The Role of Mitochondrial Genes in Neurodegenerative Disorders
| Autor: | Atiar Rahman, Gaber El-Saber Batiha, Athanasios Alexiou, Bijo Mathew, Seetha Harila, Rajesh Kumar, Della Grace Thomas Parambi, S.K. Kanthlal |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Mitochondrial DNA
Mitochondrial Diseases Mitochondrial disease SOD1 PINK1 Gene mutation Biology medicine.disease_cause DNA Mitochondrial Parkin medicine Humans Pharmacology (medical) Pharmacology Genetics Mutation Neurodegeneration Amyotrophic Lateral Sclerosis Neurodegenerative Diseases Parkinson Disease General Medicine medicine.disease Psychiatry and Mental health Genes Mitochondrial Neurology Neurology (clinical) |
| Zdroj: | Current neuropharmacology. 20(5) |
| ISSN: | 1875-6190 |
| Popis: | Mitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mitochondrial mutations that disturb the mitochondrial functions and dynamics. There is a lack of evidence linking mtDNA mutations to neurodegenerative disorders, mainly due to the absence of noticeable neuropathological lesions in postmortem samples. This review describes various gene mutations in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and stroke. These abnormalities, including PINK1, Parkin, and SOD1 mutations, seem to reveal mitochondrial dysfunctions due to either mtDNA mutation or deletion, the mechanism of which remains unclear in depth. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|