Relationships between aeroallergen levels and hospital admissions for asthma in the Brussels-Capital Region: a daily time series analysis
| Autor: | Lucie Hoebeke, Ann Packeu, Marijke Hendrickx, Koen De Cremer, An Van Nieuwenhuyse, Sandrine Bladt, Nicolas Bruffaerts, Ariane Guilbert, Olivier Brasseur, Bianca Cox |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
DISTRIBUTED LAG
RESPIRATORY-INFECTIONS Health Toxicology and Mutagenesis Air pollution 010501 environmental sciences medicine.disease_cause 01 natural sciences 0302 clinical medicine Belgium Interquartile range Child Public Environmental & Occupational Health ASSOCIATIONS Aged 80 and over Air Pollutants asthma hospitalization pollen grain fungal spore air pollution time series distributed lag model biology Incidence Incidence (epidemiology) lcsh:Public aspects of medicine Middle Aged ALLERGY Hospitalization Child Preschool Pollen grain lcsh:Industrial medicine. Industrial hygiene Fungal spore Life Sciences & Biomedicine Environmental Monitoring Adult Time series Adolescent Environmental Sciences & Ecology EMERGENCY-DEPARTMENT VISITS Young Adult 03 medical and health sciences lcsh:RC963-969 Hornbeam Pollen medicine FUNGAL SPORES Humans Cities Aged 0105 earth and related environmental sciences Asthma Science & Technology Research Infant Newborn Public Health Environmental and Occupational Health Infant Aeroallergen lcsh:RA1-1270 AIR-POLLUTION Allergens Herbaceous plant medicine.disease biology.organism_classification Distributed lag model EXACERBATIONS POLLEN COUNTS 030228 respiratory system Environmental Sciences METEOROLOGICAL CONDITIONS Demography |
| Zdroj: | Environmental Health, Vol 17, Iss 1, Pp 1-12 (2018) Environmental Health |
| Popis: | Background: Outdoor pollen grain and fungal spore concentrations have been associated with severe asthma exacerbations at the population level. The specific impact of each taxon and the concomitant effect of air pollution on these symptoms have, however, still to be better characterized. This study aimed to investigate the short-term associations between ambient concentrations of various aeroallergens and hospitalizations related to asthma in the Brussels-Capital Region (Belgium), an area recording especially high rates of admissions. Methods: Based on administrative records of asthma hospitalizations and regular monitoring of 11 tree/herbaceous pollen taxa and 2 fungal spore taxa, daily time series analyses covering the 2008-2013 period were performed. Effects up to 6 days after exposure were captured by combining quasi-Poisson regression with distributed lag models, adjusting for seasonal and long-term trends, day of the week, public holidays, mean temperature and relative humidity. Effect modification by age and air pollution (PM, NO2, O-3) was tested. Results: A significant increase in asthma hospitalizations was observed for an interquartile range increase in grass (5.9%, 95% CI: 0.0, 12.0), birch (3.2%, 95% CI: 1.1, 5.3) and hornbeam (0.7%, 95% CI: 0.2, 1.3) pollen concentrations. For several taxa including grasses, an age modification effect was notable, the hospitalization risk tending to be higher in individuals younger than 60 years. Air pollutants impacted the relationships too: the risk appeared to be stronger for grass and birch pollen concentrations in case of high PM10 and O-3 concentrations respectively. Conclusions: These findings suggest that airborne grass, birch and hornbeam pollen are associated with severe asthma exacerbations in the Brussels region. These compounds appear to act in synergy with air pollution and to more specifically affect young and intermediate age groups. Most of these life-threatening events could theoretically be prevented with improved disease diagnosis/management and targeted communication actions. This study was entirely funded by Brussels-Environment (BIM-IBGE). This organization was partly involved in the study design, the supervision of the research, data procurement and results interpretation. Bianca Cox is a postdoctoral fellow of the FWO (12Q0517N). |
| Databáze: | OpenAIRE |
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