Neosaxitoxin, a Paralytic Shellfish Poison toxin, effectively manages bucked shins pain, as a local long-acting pain blocker in an equine model
| Autor: | Gricel Riquelme, Néstor Lagos, Cecilia Montero, Zaki Al Ghumgham, Miguel del Campo, Joaquín M. Sepúlveda |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Lameness Animal Neosaxitoxin Pain Pharmacology Shellfish poison Toxicology medicine.disease_cause Infusions Subcutaneous 03 medical and health sciences chemistry.chemical_compound Periostitis 0302 clinical medicine Medicine Animals Bucked shins Local anesthesia Clinical efficacy Horses Anesthetics Local Saxitoxin business.industry Toxin 030104 developmental biology Long acting chemistry Anesthesia Horse Diseases business 030217 neurology & neurosurgery |
| Zdroj: | Toxicon : official journal of the International Society on Toxinology. 141 |
| ISSN: | 1879-3150 |
| Popis: | Local anesthesia is an effective method to control pain. Neosaxitoxin is a phycotoxin whose molecular mechanism includes a reversible inhibition of voltage-gated sodium channels at the axonal level, impeding nerve impulse propagation. The present study was designed to evaluate the clinical efficacy of Neosaxitoxin as a local long-acting pain blocker in horse bucked shins, and it was found to effectively control pain. While Neosaxitoxin and Gonyautoxin, another Paralytic Shellfish Poison (PSP) toxin, have been successfully used in humans as long-lasting pain blockers, this finding marks the first time a PSP has been shown to have an established effect in veterinary medicine. |
| Databáze: | OpenAIRE |
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