Glyconanofluorides as Immunotracers with a Tunable Core Composition for Sensitive Hotspot Magnetic Resonance Imaging of Inflammatory Activity
| Autor: | Reut Mashiach, Alisa Lubart, Andrea Galisova, Amnon Bar-Shir, David Kain, Dana Cohen, Hyla Allouche-Arnon, Pablo Blinder, Yoseph Addadi, Lothar Houben |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
19F MRI General Physics and Astronomy 02 engineering and technology 010402 general chemistry 01 natural sciences Article Fluorides Paramagnetism nanocrystals In vivo glyconanoparticles medicine Animals General Materials Science chemistry.chemical_classification medicine.diagnostic_test Biomolecule General Engineering Spin–lattice relaxation Magnetic resonance imaging biomimetic 021001 nanoscience & nanotechnology Magnetic Resonance Imaging 0104 chemical sciences chemistry inflammation Nanoparticles multicolor MRI 0210 nano-technology Biomedical engineering |
| Zdroj: | ACS Nano |
| ISSN: | 1936-086X 1936-0851 |
| Popis: | Nature-inspired nanosized formulations based on an imageable, small-sized inorganic core scaffold, on which biomolecules are assembled to form nanobiomimetics, hold great promise for both early diagnostics and developed therapeutics. Nevertheless, the fabrication of nanobiomimetics that allow noninvasive background-free mapping of pathological events with improved sensitivity, enhanced specificity, and multiplexed capabilities remains a major challenge. Here, we introduce paramagnetic glyconanofluorides as small-sized ( |
| Databáze: | OpenAIRE |
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