TRIM59 Protects Mice From Sepsis by Regulating Inflammation and Phagocytosis in Macrophages
| Autor: | Zhenhua Zhu, Yuan Tian, Pei Zhu, Shanshan Liu, Zheng Jin, Dong Li, Mengyan Tang, Dongmei Yan, Yuyang Hou, Xun Zhu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine Lipopolysaccharide Phagocytosis Immunology Inflammation sepsis Tripartite Motif Proteins Sepsis Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Immunology and Allergy TRIM59 Receptor Immune cell infiltration Cells Cultured Original Research Lung biology business.industry Macrophages Receptors IgG Intracellular Signaling Peptides and Proteins NF-kappa B phagocytosis biology.organism_classification medicine.disease Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Neutrophil Infiltration chemistry Cytokines medicine.symptom lcsh:RC581-607 business Bacteria Signal Transduction 030215 immunology |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 11 (2020) |
| ISSN: | 1664-3224 |
| Popis: | Sepsis is associated with bacterial invasion and inflammation and has a high mortality rate. Previous studies have demonstrated that tripartite motif 59 (TRIM59) was involved in NF-κB signaling and could promote phagocytosis of macrophages, but the role of TRIM59 in sepsis is still unknown. In our study, we found that TRIM59 was downregulated in lipopolysaccharide (LPS)-stimulated bone marrow-derived macrophages (BMDMs). In the cecal ligation and puncture (CLP) sepsis mice model, the mortality of Trim59flox/floxLyz-Cre (Trim59-cKO) mice was higher, the immune cell infiltration and damage of liver and lung were more severe, and bacteria burden was increased. We also found that TRIM59 altered the production of pro-inflammation cytokines, as well as macrophage phagocytosis ability. Further analysis indicated that NF-κB signal pathway and Fcγ receptors might be involved in these regulations. Our study demonstrated for the first time that TRIM59 protects mice from sepsis by regulating inflammation and phagocytosis in macrophages. |
| Databáze: | OpenAIRE |
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