Association of vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients
| Autor: | Lucio Boglione, Giuseppe Cariti, Jessica Cusato, Chiara Carcieri, Giovanni Di Perri, Valeria Ghisetti, Amedeo De Nicolò, Rosaria Imbornone, Chiara Simona Cardellino, Antonio D'Avolio |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male calcitriol 0301 basic medicine HBsAg Alpha interferon Biology medicine.disease_cause Antiviral Agents Polymorphism Single Nucleotide Calcitriol receptor Cohort Studies 03 medical and health sciences 0302 clinical medicine Pegylated interferon Genetics medicine Vitamin D and neurology Humans Hepatitis B e Antigens Vitamin D Retrospective Studies pharmacogenetics Pharmacology Hepatitis B virus Interferon-alpha Middle Aged Hepatitis B VDR genes medicine.disease Treatment Outcome 030104 developmental biology Immunology Receptors Calcitriol Molecular Medicine Female 030211 gastroenterology & hepatology Viral load Signal Transduction medicine.drug |
| Zdroj: | Pharmacogenomics. 18:651-661 |
| ISSN: | 1744-8042 1462-2416 |
| Popis: | Aim: Vitamin D modulates biological processes; an influence of vitamin D levels and genetic variants was identified concerning hepatitis B virus infection. We evaluated the role of some SNPs of vitamin D pathway genes in some clinical features of hepatitis B affected patients treated with pegylated interferon. Methods: We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP and VDR genes, through real-time PCR. Results: VDRApaI SNP was associated to viral load and HBsAg presence at different timings. In logistic regression analyses, VDRApaI AA genotype predicted baseline viral load >6 Log IU/ml (marker of nonresponse), and both virological and biochemical responses. Conclusion: Pharmacogenetic data could help physicians in the prediction of patients with higher probability to achieve a good response. |
| Databáze: | OpenAIRE |
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