Hodgkin lymphoma in very young children: Clinical characteristics and outcome of treatment
| Autor: | Yasser Khafaga, Asim F. Belgaumi, Nicey Joseph, Rubina Jamil-Malik, Amani Al-Kofide, Rajeh Sabbah |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Treatment outcome Internal medicine Humans Medicine Combined Modality Therapy Child Retrospective Studies Chemotherapy business.industry Infant Newborn Infant Retrospective cohort study Hematology Hodgkin Disease Treatment Outcome Child Preschool Toxicity Hodgkin lymphoma Female Dose reduction business Developed country |
| Zdroj: | Leukemia & Lymphoma. 49:910-916 |
| ISSN: | 1029-2403 1042-8194 |
| Popis: | In developed nations, Hodgkin lymphoma (HL) is rare in5-year olds and represent a minority in developing countries. Little is reported about the biology and behavior of these very young patients compared with older children. 18.75% of our pediatric HL patients (0 - 14 years) were5 years at diagnosis. This group had more boys, similar incidence of B-symptoms and stage distribution, less mediastinal involvement and bulky disease, and more mixed cellularity subtype than older children. Treatment included chemotherapy (CT; n = 55), combined modality therapy (CMT; n = 12) and XRT only (n = 2). Ten-year EFS and OS was 81.5% and 90.4%, respectively, versus 75.5% and 90.5% for older children (p0.5). A trend toward better survival was seen with CMT, using very LD-XRT, than with CT (OS 100% vs. 86.4%[p = 0.3]; EFS 90.9% vs. 81.0%[p = 0.4]). Although CT could be effective in a subset of LR patients, LD-XRT may be needed to effectively treat most of these patients. This dose reduction may reduce XRT-related toxicity, which can be significant in very young children. |
| Databáze: | OpenAIRE |
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