Cholesterol mass efflux capacity and risk of peripheral artery disease: The Multi-Ethnic Study of Atherosclerosis

Autor: Parveen K. Garg, Steven Shea, Matthew A. Allison, James H. Stein, Laurent Yvan-Chavret, Robyn L. McClelland, Neal W. Jorgensen, Alan R. Tall
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Aging
Time Factors
THP-1 Cells
Arterial disease
Disease
Cardiorespiratory Medicine and Haematology
030204 cardiovascular system & hematology
Cardiovascular
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
80 and over
2.1 Biological and endogenous factors
Medicine
Aetiology
Subclinical infection
Aged
80 and over
Incidence
Hazard ratio
Middle Aged
Prognosis
Cholesterol
Cardiology
Female
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
HDL
Clinical Sciences
Risk Assessment
Article
Peripheral Arterial Disease
03 medical and health sciences
Clinical Research
Internal medicine
Humans
Ankle Brachial Index
Aged
business.industry
Proportional hazards model
Prevention
Macrophages
Cholesterol
HDL
Atherosclerosis
United States
body regions
030104 developmental biology
Cardiovascular System & Hematology
chemistry
Case-Control Studies
Relative risk
business
Biomarkers
Lipoprotein
Zdroj: Atherosclerosis
ISSN: 0021-9150
Popis: Background and aims We aimed to assess the relationship of HDL (high-density lipoprotein)-mediated cholesterol mass efflux capacity (CMEC) with risk of incident peripheral artery disease (PAD). Methods CMEC was measured in 1458 Multi-Ethnic Study of Atherosclerosis participants between 2000 and 2002 as part of a case-control study matched for incident cardiovascular disease and progression of carotid plaque by ultrasound. Incident clinical PAD, adjudicated on the basis of a positive history for the presence of disease-related symptoms or treatment, was ascertained through 2015 in 1419 individuals without clinical PAD at baseline. Subclinical PAD, defined as an ankle-brachial index (ABI) ≤1.0, was assessed among 1255 individuals with a baseline ABI > 1.0 and at least one follow-up ABI measurement 3–10 years later. Cox proportional hazards and relative risk regression modeling per SD increment of CMEC were used to determine the association of CMEC with clinical and subclinical PAD, respectively. Results There were 38 clinical PAD and 213 subclinical PAD events that occurred over a mean follow-up of 6.0 and 6.5 years respectively. After adjustment for age, gender, and race, higher CMEC levels were not associated with clinical PAD (hazard ratio 1.25; 95% CI 0.89, 1.75) or subclinical PAD (risk ratio 1.02; 95% CI, 0.94, 1.11). Conclusions These findings suggest that HDL-mediated cholesterol efflux is not significantly associated with incident clinical and subclinical PAD.
Databáze: OpenAIRE
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