Cholesterol mass efflux capacity and risk of peripheral artery disease: The Multi-Ethnic Study of Atherosclerosis
Autor: | Parveen K. Garg, Steven Shea, Matthew A. Allison, James H. Stein, Laurent Yvan-Chavret, Robyn L. McClelland, Neal W. Jorgensen, Alan R. Tall |
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Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Aging Time Factors THP-1 Cells Arterial disease Disease Cardiorespiratory Medicine and Haematology 030204 cardiovascular system & hematology Cardiovascular chemistry.chemical_compound 0302 clinical medicine Risk Factors 80 and over 2.1 Biological and endogenous factors Medicine Aetiology Subclinical infection Aged 80 and over Incidence Hazard ratio Middle Aged Prognosis Cholesterol Cardiology Female Cardiology and Cardiovascular Medicine medicine.medical_specialty HDL Clinical Sciences Risk Assessment Article Peripheral Arterial Disease 03 medical and health sciences Clinical Research Internal medicine Humans Ankle Brachial Index Aged business.industry Proportional hazards model Prevention Macrophages Cholesterol HDL Atherosclerosis United States body regions 030104 developmental biology Cardiovascular System & Hematology chemistry Case-Control Studies Relative risk business Biomarkers Lipoprotein |
Zdroj: | Atherosclerosis |
ISSN: | 0021-9150 |
Popis: | Background and aims We aimed to assess the relationship of HDL (high-density lipoprotein)-mediated cholesterol mass efflux capacity (CMEC) with risk of incident peripheral artery disease (PAD). Methods CMEC was measured in 1458 Multi-Ethnic Study of Atherosclerosis participants between 2000 and 2002 as part of a case-control study matched for incident cardiovascular disease and progression of carotid plaque by ultrasound. Incident clinical PAD, adjudicated on the basis of a positive history for the presence of disease-related symptoms or treatment, was ascertained through 2015 in 1419 individuals without clinical PAD at baseline. Subclinical PAD, defined as an ankle-brachial index (ABI) ≤1.0, was assessed among 1255 individuals with a baseline ABI > 1.0 and at least one follow-up ABI measurement 3–10 years later. Cox proportional hazards and relative risk regression modeling per SD increment of CMEC were used to determine the association of CMEC with clinical and subclinical PAD, respectively. Results There were 38 clinical PAD and 213 subclinical PAD events that occurred over a mean follow-up of 6.0 and 6.5 years respectively. After adjustment for age, gender, and race, higher CMEC levels were not associated with clinical PAD (hazard ratio 1.25; 95% CI 0.89, 1.75) or subclinical PAD (risk ratio 1.02; 95% CI, 0.94, 1.11). Conclusions These findings suggest that HDL-mediated cholesterol efflux is not significantly associated with incident clinical and subclinical PAD. |
Databáze: | OpenAIRE |
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