Acyl-CoA synthetase long-chain 5 genotype is associated with body composition changes in response to lifestyle interventions in postmenopausal women with overweight and obesity: a genetic association study on cohorts Montréal-Ottawa New Emerging Team, and Complications Associated with Obesity
| Autor: | Denis Prud'homme, Mary-Ellen Harper, Pierrette M. Bolongo, Gilles Lamothe, Kristi B. Adamo, Frédérique Tesson, Rémi Rabasa-Lhoret, Éric Doucet, Abishankari Rajkumar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Canada medicine.medical_specialty Genotype Diet Reducing 030209 endocrinology & metabolism Overweight Biology Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Weight loss Internal medicine Coenzyme A Ligases Lifestyle intervention Genetics medicine Humans Genetics(clinical) Obesity Precision Medicine Genetic Association Studies Genetics (clinical) Caloric Restriction Genetic association 2. Zero hunger Acyl-CoA synthetase Postmenopausal women Middle Aged medicine.disease Lifestyle modifications 3. Good health Postmenopause 030104 developmental biology Endocrinology Body Composition Regression Analysis Female medicine.symptom Fat metabolism Research Article |
| Zdroj: | BMC Medical Genetics |
| ISSN: | 1471-2350 |
| DOI: | 10.1186/s12881-016-0320-4 |
| Popis: | Background Genetic studies on Acyl-CoA Synthetase Long-Chain 5 (ACSL5) demonstrate an association between rs2419621 genotype and rate of weight loss in women with obesity in response to caloric restriction. Our objectives were to (1) confirm results in two different populations of women with overweight and obesity (2) study rs2419621’s influence on body composition parameters of women with overweight and obesity following lifestyle interventions. Methods rs2419621 genotype was determined in women with overweight and obesity who participated in the Montréal-Ottawa New Emerging Team (MONET n = 137) and Complications Associated with Obesity (CAO n = 37) studies. Genotyping was done using TaqMan MGB probe-based assay. Multiple linear regression analyses were used to test for associations. Results When studying women with overweight and obesity, rs2419621 [T] allele carriers had a significantly greater decrease in visceral fat, absolute and percent fat mass and a greater increase in percent lean mass in response to lifestyle intervention in comparison to non-carriers. Studying only individuals with obesity showed similar results with rs2419621 [T] allele carriers also displaying a significantly greater decrease in body mass index following the lifestyle intervention in comparison to non-carriers. Conclusion Women with overweight and obesity carrying the ACSL5 rs2419621 [T] allele are more responsive to lifestyle interventions in comparison to non-carriers. Conducting such genetic association studies can aid in individualized treatments/interventions catered towards an individual’s genotype. |
| Databáze: | OpenAIRE |
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