The Insect Prothoracic Gland as a Model for Steroid Hormone Biosynthesis and Regulation
| Autor: | Naoki Yamanaka, Jie Zeng, Kirst King-Jones, Qiuxiang Ou, Christina Brakken-Thal, Michael B. O'Connor |
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| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Time Factors medicine.medical_treatment Messenger Medical Physiology Genes Insect Halloween genes chemistry.chemical_compound 0302 clinical medicine Models Drosophila Proteins nuclear receptor ecdysone lcsh:QH301-705.5 Torso Prothoracic gland Cell biology Circadian Rhythm corpus allatum Drosophila melanogaster Organ Specificity ring gland Steroids RNA Interference Drosophila Drosophila Protein Ecdysone Biotechnology medicine.medical_specialty cytochrome P450 1.1 Normal biological development and functioning Nocturnin Biology Real-Time Polymerase Chain Reaction Models Biological Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Underpinning research Internal medicine medicine Genetics Animals RNA Messenger Bombyx Gene Expression Profiling Neuropeptides fungi Animal Structures biology.organism_classification Biological Hormones Steroid hormone 030104 developmental biology Endocrinology Nuclear receptor chemistry lcsh:Biology (General) Gene Expression Regulation Genes PTTH RNA corpus cardiacum Biochemistry and Cell Biology Insect 030217 neurology & neurosurgery Hormone Ras |
| Zdroj: | Cell reports, vol 16, iss 1 Cell Reports, Vol 16, Iss 1, Pp 247-262 (2016) |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2016.05.053 |
| Popis: | SummarySteroid hormones are ancient signaling molecules found in vertebrates and insects alike. Both taxa show intriguing parallels with respect to how steroids function and how their synthesis is regulated. As such, insects are excellent models for studying universal aspects of steroid physiology. Here, we present a comprehensive genomic and genetic analysis of the principal steroid hormone-producing organs in two popular insect models, Drosophila and Bombyx. We identified 173 genes with previously unknown specific expression in steroid-producing cells, 15 of which had critical roles in development. The insect neuropeptide PTTH and its vertebrate counterpart ACTH both regulate steroid production, but molecular targets of these pathways remain poorly characterized. Identification of PTTH-dependent gene sets identified the nuclear receptor HR4 as a highly conserved target in both Drosophila and Bombyx. We consider this study to be a critical step toward understanding how steroid hormone production and release are regulated in all animal models. |
| Databáze: | OpenAIRE |
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