Oxytocin use during Caesarean sections in Denmark - are we getting the dose right?
| Autor: | Bjarne Nordstrøm Kjær, Mogens Krøigaard, Lene Heise Garvey |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Denmark Provocation test Oxytocin law.invention Cohort Studies Drug Hypersensitivity Young Adult 03 medical and health sciences 0302 clinical medicine Bolus (medicine) Randomized controlled trial Pregnancy 030202 anesthesiology law Oxytocics Atony medicine Humans Retrospective Studies 030219 obstetrics & reproductive medicine Dose-Response Relationship Drug Cesarean Section Obstetrics business.industry Retrospective cohort study General Medicine medicine.disease Telephone Anesthesiology and Pain Medicine Health Care Surveys Anesthesia Female Tryptases medicine.symptom business hormones hormone substitutes and hormone antagonists Cohort study medicine.drug |
| Zdroj: | Kjaer, B N, Krøigaard, M & Garvey, L H 2016, ' Oxytocin use during Caesarean sections in Denmark-are we getting the dose right? ', Acta Anaesthesiologica Scandinavica, vol. 60, no. 1, pp. 18-25 . https://doi.org/10.1111/aas.12603 |
| ISSN: | 0001-5172 |
| Popis: | Background In Denmark, an iv bolus of 10 IU oxytocin was traditionally given after delivery to prevent atony during caesarean sections. Randomized controlled trials have shown that lower iv bolus doses have same efficacy with fewer side effects and many countries now recommend a 5 IU maximum dose. The aims of this study were to investigate whether patients referred for allergy testing after oxytocin exposure had dose-related side effects to oxytocin rather than true allergic reactions and to investigate whether updated international recommendations on lower bolus doses had been implemented in practice. Methods Medical notes of patients tested with oxytocin as part of investigations in the Danish Anaesthesia Allergy Centre from May 2004 to January 2014 were reviewed retrospectively. A telephone survey of on-duty obstetricians at all Danish obstetric departments was performed and most recent online recommendations from the Danish societies of obstetrics and anaesthesia about the use of oxytocin were identified. Results In total 30 women were tested with oxytocin as part of investigations. None were allergic to oxytocin but 19 had symptoms consistent with dose-related side effects on iv provocation. The telephone survey revealed that iv doses of 10 IU oxytocin were still used and recommendations on the websites were not updated. Conclusion Too high oxytocin doses are still used in Denmark leading to dose-related side effects mimicking allergic reactions. Coordination between obstetricians and anaesthesiologists on producing common updated guidelines on the administration of oxytocin and dissemination of this information to obstetric and anaesthetic departments in Denmark is needed. |
| Databáze: | OpenAIRE |
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