| Autor: |
Masafumi Ueno, Salvatore D. Tomasello, Theodore A. Bass, Luis A. Guzman, Murali Kodali, Antonio Tello-Montoliu, Naveen Seecheran, Dominick J. Angiolillo, Bhaloo Desai, Martin M. Zenni, José Luis Ferreiro, Lyndon C. Box, Ronald K. Charlton |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Journal of the American College of Cardiology. 59(19):1681-1687 |
| ISSN: |
0735-1097 |
| DOI: |
10.1016/j.jacc.2011.12.039 |
| Popis: |
Objectives The purpose of this study is to assess the pharmacodynamic effects of different prasugrel dosing regimens in patients on maintenance prasugrel therapy. Background There are a growing number of patients on chronic prasugrel therapy regimens, leading to questions about the dosing regimen of prasugrel to administer if percutaneous coronary intervention is required. Methods This is a prospective pharmacodynamic study in patients (n = 64) receiving maintenance prasugrel therapy who were randomly allocated to a 10 mg, 30 mg, or 60 mg dose of prasugrel. Pharmacodynamic assessments using multiple assays were conducted at 3 timepoints (baseline and 1 h and 4 h after dosing). Results Intragroup comparisons showed that a 60 mg dose reduced the platelet reactivity index (PRI) after 1 h (p = 0.004) and 4 h (p Conclusions For patients on maintenance prasugrel therapy, a 60 mg dosing strategy is associated with faster and higher platelet inhibition compared with lower doses, as assessed by P2Y12 specific assays. (Impact of Prasugrel Re-load on Platelet Aggregation in Patients on Chronic Prasugrel Therapy; NCT01201772) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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