| Autor: |
Almouhanna, Fadi, Blagojevic, Biljana, Can, Suzan, Ghanem, Ali, Wölfl, Stefan |
| Rok vydání: |
2021 |
| Předmět: |
|
| DOI: |
10.6084/m9.figshare.13633205.v1 |
| Popis: |
Additional file 4: Supplementary Figure S4. PKM2 activation does not change G6PD activity . (A) G6PD activity in crude extract of BCa cells in response to DASA-58 (15μM), data presented as absorbance values at 340 nm resulting from the buildup of NADPH. (B) intracellular ROS levels in MCF7 and T47-D cells in response to either DASA-58 (15μM) alone or followed by 2 h of H2O2 (200 μM) treatment. Daggers (†) are used to indicate statistical significance between the single and combo treatment. (C) Total protein staining using SRB assay showing the relative survival of MCF7 cells in response to DASA-58 (15 μM) in the absence of serine. Data are presented as % survival normalized to the mock treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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