Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters
| Autor: | Nagwa Ramadan Ahmed, Nehal Hamdy El-said, Noha Adly Sadik, Sherry Elisha Fayez, Nagwa Abd El-Ghaffar Mohammed |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Adipokine 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Diabetes mellitus Internal medicine medicine Glucose homeostasis Obesity Omentin-1 Glycemic medicine.diagnostic_test business.industry Insulin medicine.disease Lipid profile business Research Paper |
| Zdroj: | Journal of Clinical & Translational Endocrinology |
| ISSN: | 2214-6237 |
| DOI: | 10.1016/j.jcte.2018.05.003 |
| Popis: | Background Omentin-1 a new anti-inflammatory adipokine has been identified as a major visceral (omental) secretory adipokine which plays important roles in glucose homeostasis, lipid metabolism, insulin resistance and diabetes. The aim of our study was to evaluate serum omentin-1 levels in type 2 diabetic obese females and assess its relation with glycemic control, insulin resistance and metabolic parameters. Methods The study included 60 obese type 2 diabetic females and 30 healthy female subjects formed the control group. They subjected to full clinical examination, weight, height, waist and hip circumference. Fasting (blood glucose, insulin, lipid profile, omentin-1) and HbA1c were measured. BMI and HOMA-IR were calculated. Our data analyzed and expressed in terms of mean ± SD. Pearson correlation performed to study the correlation of serum omentin-1 in relation to glycemic control, insulin resistance and metabolic parameters in the studied groups. Results We found significant decrease in serum omentin-1 levels in cases with mean ± SD (16.5 ± 2.6 pg/ml) compared to controls (25.3 ± 1.0 pg/ml) (P |
| Databáze: | OpenAIRE |
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