Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeys
| Autor: | Jack H. Mendelson, S. Stevens Negus, Kenner C. Rice, Nancy K. Mello |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Acute effects Hypothalamo-Hypophyseal System medicine.medical_specialty Corticotropin-Releasing Hormone medicine.drug_class Sedation Clinical Biochemistry Pituitary-Adrenal System Self Administration Pharmacology Toxicology Biochemistry Corticotropin-releasing hormone receptor 1 Cocaine-Related Disorders Behavioral Neuroscience Discrimination Psychological Cocaine Internal medicine medicine Animals Pyrroles Antalarmin Biological Psychiatry Antagonist Receptor antagonist Macaca mulatta Pyrimidines Endocrinology Female medicine.symptom Psychology Stimulus control Self-administration medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 85:744-751 |
| ISSN: | 0091-3057 |
| Popis: | Cocaine stimulates the rapid release of ACTH, and by inference, CRF in several species, suggesting that the HPA “stress” axis may contribute to the abuse-related effects of cocaine. The effects of a systemically-active CRF 1 receptor antagonist, antalarmin, on cocaine self-administration and cocaine discrimination were examined in rhesus monkeys. Antalarmin's acute (1–10 mg/kg, IV) and chronic (3.2 mg/kg IV) effects on IV cocaine self-administration were studied. The acute effects of 3.2 mg/kg IV antalarmin on the cocaine self-administration dose–effect curve (0.001–0.10 mg/kg/inj) were also examined. The acute effects of antalarmin (5 and 10 mg/kg, IM) on the cocaine discrimination dose–effect curve (0.013–1.3 mg/kg) were examined. Antalarmin did not significantly decrease the reinforcing or the discriminative stimulus effects of cocaine. Acute antalarmin administration produced a dose-dependent but non-significant decrease in self-administration of 0.01 mg/kg/inj cocaine but did not alter the cocaine dose–effect curve. Chronic daily antalarmin treatment did not significantly decrease cocaine-maintained responding. Antalarmin did not significantly alter either the cocaine discrimination dose–effect curve or the time course of the cocaine-training dose. Antalarmin (10 mg/kg) produced sedation, suggesting that it was centrally active, however, it did not attenuate cocaine's abuse-related effects in rhesus monkeys. |
| Databáze: | OpenAIRE |
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