Restriction Factors: From Intrinsic Viral Restriction to Shaping Cellular Immunity Against HIV-1

Autor: Alba Ruiz, Julia G. Prado, Marta Colomer-Lluch, Arnaud Moris
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
CD4-Positive T-Lymphocytes
Cellular immunity
HIV Infections
Review
APOBEC-3G Deaminase
Virus Replication
Antiviral Restriction Factors
Tripartite Motif Proteins
Immunology and Allergy
innate immunity
Innate immunity
degradation pathways
Immunity
Cellular
adaptive immunity
Acquired immune system
Virus
Host-Pathogen Interactions
RNA
Viral
lcsh:Immunologic diseases. Allergy
Ubiquitin-Protein Ligases
Immunology
Adaptive immunity
virus
Biology
Protein degradation
GPI-Linked Proteins
SAM Domain and HD Domain-Containing Protein 1
03 medical and health sciences
Immune system
Antigens
CD
Humans
Degradation pathways
Innate immune system
030102 biochemistry & molecular biology
Virion
immunotherapies
restriction factors
Immunity
Innate
030104 developmental biology
Viral replication
Proteolysis
Tetherin
HIV-1
Restriction factors
Carrier Proteins
Immunotherapies
lcsh:RC581-607
SAMHD1
Zdroj: Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
ISSN: 1664-3224
Popis: Antiviral restriction factors are host cellular proteins that constitute a first line of defense blocking viral replication and propagation. In addition to interfering at critical steps of the viral replication cycle, some restriction factors also act as innate sensors triggering innate responses against infections. Accumulating evidence suggests an additional role for restriction factors in promoting antiviral cellular immunity to combat viruses. Here, we review the recent progress in our understanding on how restriction factors, particularly APOBEC3G, SAMHD1, Tetherin, and TRIM5α have the cell-autonomous potential to induce cellular resistance against HIV-1 while promoting antiviral innate and adaptive immune responses. Also, we provide an overview of how these restriction factors may connect with protein degradation pathways to modulate anti-HIV-1 cellular immune responses, and we summarize the potential of restriction factors-based therapeutics. This review brings a global perspective on the influence of restrictions factors in intrinsic, innate, and also adaptive antiviral immunity opening up novel research avenues for therapeutic strategies in the fields of drug discovery, gene therapy, and vaccines to control viral infections.
Databáze: OpenAIRE
Externí odkaz: