New prenylflavonol glycosides with xanthine oxidase inhibitory activity from the leaves of Cyclocarya paliurus
| Autor: | Gang-Zhi Zhu, Wen-Yan Lv, Jing Li, Wen-Xuan Wang, Hui Zhu, Zu-Hui Chen, Hui-Hui Sun, Xiao-Ai He, Zi-Jun Ye, Kang-Ping Xu, Jie Tan, Xi-Wen Chang, Jian-Ping Wu |
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| Rok vydání: | 2020 |
| Předmět: |
Xanthine Oxidase
Flavonols Inhibitory postsynaptic potential 01 natural sciences Biochemistry Juglandaceae Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Bioassay Glycosides Enzyme Inhibitors Xanthine oxidase Molecular Biology chemistry.chemical_classification Chromatography biology Plant Extracts 010405 organic chemistry Chemistry Spectrum Analysis Organic Chemistry Glycoside biology.organism_classification 0104 chemical sciences Plant Leaves 010404 medicinal & biomolecular chemistry Paliurus Acid hydrolysis Two-dimensional nuclear magnetic resonance spectroscopy Cyclocarya |
| Zdroj: | Bioorganic Chemistry. 101:104018 |
| ISSN: | 0045-2068 |
| DOI: | 10.1016/j.bioorg.2020.104018 |
| Popis: | Eight new prenylflavonol glycosides (1–8), along with five known analogues (9–13) were isolated from the n-butanol extract of the dried leaves of Cyclocarya paliurus (family Juglandaceae) for the first time. The structures of these compounds were characterized by comprehensive analysis of 1D, 2D NMR, HRESIMS, UV data and acid hydrolysis. In bioassay, all these thirteen prenylflavonol glycosides exhibited inhibitory effects on xanthine oxidase (XOD) activity. Especially compounds 2 and 7, showed outstanding IC50 values of 31.81 ± 2.20 and 29.71 ± 3.69 μM, respectively. |
| Databáze: | OpenAIRE |
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