The Genome of Th17 Cell-Inducing Segmented Filamentous Bacteria Reveals Extensive Auxotrophy and Adaptations to the Intestinal Environment
| Autor: | Dan R. Littman, Joseph F. Petrosino, Xiang Qin, Ivaylo I. Ivanov, Dirk Gevers, Curtis Huttenhower, Andrew Sczesnak, Nicola Segata |
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| Rok vydání: | 2011 |
| Předmět: |
Cancer Research
Auxotrophy Segmented filamentous bacteria Molecular Sequence Data Biology Bacterial Physiological Phenomena medicine.disease_cause Microbiology Genome Article Mice 03 medical and health sciences 0302 clinical medicine Virology Immunology and Microbiology(all) medicine Animals Humans Gene Molecular Biology 030304 developmental biology Clostridium Genetics Whole genome sequencing 0303 health sciences Bacteria Host (biology) Clostridiales Mycoplasma Adaptation Physiological Intestines Mice Inbred C57BL Th17 Cells Parasitology Genome Bacterial 030215 immunology |
| Zdroj: | Cell Host & Microbe. 10(3):260-272 |
| ISSN: | 1931-3128 |
| DOI: | 10.1016/j.chom.2011.08.005 |
| Popis: | Summary Perturbations of the composition of the symbiotic intestinal microbiota can have profound consequences for host metabolism and immunity. In mice, segmented filamentous bacteria (SFB) direct the accumulation of potentially proinflammatory Th17 cells in the intestinal lamina propria. We present the genome sequence of SFB isolated from monocolonized mice, which classifies SFB phylogenetically as a unique member of Clostridiales with a highly reduced genome. Annotation analysis demonstrates that SFB depend on their environment for amino acids and essential nutrients and may utilize host and dietary glycans for carbon, nitrogen, and energy. Comparative analyses reveal that SFB are functionally related to members of the genus Clostridium and several pathogenic or commensal "minimal" genera, including Finegoldia , Mycoplasma , Borrelia , and Phytoplasma . However, SFB are functionally distinct from all 1200 examined genomes, indicating a gene complement representing biology relatively unique to their role as a gut commensal closely tied to host metabolism and immunity. |
| Databáze: | OpenAIRE |
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