Progression of Macular Atrophy in Pattern Dystrophies
| Autor: | Eric H. Souied, Camille Jung, Oudy Semoun, Céline Mebsout Pallado, Anne Sikorav |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male 030103 biophysics medicine.medical_specialty Fovea Centralis Time Factors genetic structures Fundus Oculi Retinal Pigment Epithelium 03 medical and health sciences Macular Degeneration 0302 clinical medicine Atrophy Interquartile range Ophthalmology Medicine Humans Aged Retrospective Studies Retina business.industry Macular atrophy Genetic data medicine.disease eye diseases Fundus autofluorescence Decreased vision Ophthalmoscopy medicine.anatomical_structure Choroidal neovascularization 030221 ophthalmology & optometry Disease Progression Female sense organs medicine.symptom business Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | Ophthalmic surgery, lasersimaging retina. 47(7) |
| ISSN: | 2325-8179 |
| Popis: | BACKGROUND AND OBJECTIVE: To quantify the progression of macular atrophy associated with pattern dystrophies (PD). PATIENTS AND METHODS: Retrospective, observational study including patients with reticular PD and macular atrophy. A detailed ophthalmologic exam was performed, and progression of macular atrophy areas was evaluated on fundus autofluorescence frames using RegionFinder software, a semiautomated software embedded in Spectralis device (Heidelberg Engineering, Heidelberg, Germany). RESULTS: We included 19 eyes of 12 patients. The median follow-up was 4.5 years (interquartile range [IQR]: 2.7–5.5). Three eyes (16%) had choroidal neovascularization. Atrophy involved foveal area in 21% (four of 19) of cases. Decreased vision occurred in three eyes (16%). The median atrophy progression rate evaluated by RegionFinder software was 0.101 mm 2 /year (IQR: 0.054–0.257). CONCLUSION: The progression of macular atrophy in PDs appears to be relatively slow. Further studies are necessary to correlate the progression of atrophy in PDs with genetic data. [ Ophthalmic Surg Lasers Imaging Retina . 2016;47:652–658.] |
| Databáze: | OpenAIRE |
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