Improving Survival Results after Surgical Management of Malignant Pleural Mesothelioma: An Australian Institution Experience
| Autor: | Mo Mo Tin, Christopher Cao, Catherine Kennedy, Paul G. Bannon, Jocelyn McLean, Michael Boyer, Brian C. McCaughan, Tristan D. Yan |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Mesothelioma Pulmonary and Respiratory Medicine Extrapleural Pneumonectomy medicine.medical_specialty Time Factors Pleural Neoplasms medicine.medical_treatment Kaplan-Meier Estimate Risk Assessment Risk Factors Humans Medicine Prospective Studies Prospective cohort study Survival rate Aged Proportional Hazards Models Surgical team Chi-Square Distribution business.industry Proportional hazards model Gastroenterology General Medicine Middle Aged Thoracic Surgical Procedures Decortication Surgery Survival Rate Treatment Outcome Pemetrexed Chemotherapy Adjuvant Female Radiotherapy Adjuvant New South Wales Cardiology and Cardiovascular Medicine business Pleurodesis medicine.drug |
| Zdroj: | Annals of Thoracic and Cardiovascular Surgery. 17:243-249 |
| ISSN: | 2186-1005 1341-1098 |
| Popis: | Background: There has been an evolving role of surgery for malignant pleural mesothelioma (MPM) over the past 25 years. The objective of this study was to investigate whether the survival results for MPM patients after surgery have improved within this time period by an analysis of a prospective cohort of 540 patients.Methods: Five hundred and forty consecutive patients with MPM were treated by a thoracic surgical team. These patients were categorized into two groups: Group I (before September 1999, n = 270) and Group II (after September 1999, n = 270). The two groups were compared for clinicopathologic data and survival results. The statistical analyses of all prognostic parameters used overall survival as the endpoint.Results: Group II had higher proportions of epithelial tumors and patients who had preoperative PET scan, extrapleural pneumonectomy (EPP), postoperative radiotherapy and pemetrexed chemotherapy. The overall survival results were significantly better in Group II compared with Group I (p = 0.004). Four factors were found to be independently associated with an improved survival in multivariate analysis: epithelial subtype (p 100 cases (p = 0.006), patients who underwent EPP (p = 0.001) and those who received pemetrexed chemotherapy (p = 0.016). The median survival for patients selected for EPP was 20 months, as compared to 9 months for pleurodesis/decortication and pleurodesis.Conclusions: Significant improvement of overall survival results has been achieved in the more recent 270 MPM patients through accumulated experience in a specialist treatment center. |
| Databáze: | OpenAIRE |
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