Autor: |
Darrin William Hopper, Elisabeth A. Morris, David Brian How, Manus Ipek, Erica Reifenberg, Phaik-Eng Sum, Matthew D. Vera, Eric Feyfant, Katy E. Georgiadis, Jerauld S. Skotnicki, Manas K. Majumdar, Jennifer R. Thomason, Qin Wang, Joshua James Sabatini, Cristin C. Keohan, Richard Sheldon, Jason Shaoyun Xiang, Yonghan Hu |
Rok vydání: |
2009 |
Předmět: |
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Zdroj: |
Bioorganic & Medicinal Chemistry Letters. 19:2487-2491 |
ISSN: |
0960-894X |
Popis: |
The prevention of aggrecan (a key component of cartilage) cleavage via the inhibition of aggrecanase-1 may provide a unique opportunity to stop the progression of cartilage degradation in osteoarthritis. The evaluation of a series of biphenylsulfonamides resulted in the identification of the ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides analogs (19-21 and 24) with improved Agg-1 inhibition and MMP-2, MMP-13 activity. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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