Reduced joint pain after short-term duodenal administration of seal oil in patients with inflammatory bowel disease: comparison with soy oil
| Autor: | Beate Klementsen, Arnold Berstad, Gülen Arslan, Livar Frøyland, Johan G. Brun, Ragna Lind, Linn Anne Brunborg, Tormod Bjørkkjær, Merete Valen |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Exacerbation Duodenum Medisinske Fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759 [VDP] Arthritis Gastroenterology Inflammatory bowel disease Fatty Acids Omega-6 Internal medicine Fatty Acids Omega-3 Animals Humans Medicine Intubation Gastrointestinal Medisinske Fag: 700::Klinisk medisinske fag: 750::Gasteroenterologi: 773 [VDP] business.industry Fur Seals Fatty Acids Area under the curve Middle Aged Inflammatory Bowel Diseases medicine.disease Arthralgia Eicosapentaenoic acid Ulcerative colitis Soybean Oil medicine.anatomical_structure Joint pain Female medicine.symptom business |
| Zdroj: | Scandinavian Journal of Gastroenterology. 39:1088-1094 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.1080/00365520410009429 |
| Popis: | Background: Rheumatic joint pain is a common extra-intestinal complication of inflammatory bowel disease (IBD). Because the high ratio of n-6 to n-3 fatty acids (FAs) of the Western diet might promote rheumatic disorders, we sought to compare the effects of short-term duodenal administration of n-3-rich seal oil and n-6-rich soy oil on IBD-related joint pain. Methods: Nineteen patients with IBD-related joint pain were included in the study; 9 had Crohn disease and 10 had ulcerative colitis. Ten millilitres seal oil (n = 10) or soy oil (n = 9) was self-administered through a nasoduodenal feeding tube 3 times daily for 10 days. Results: Compared with soy oil treatment, seal oil significantly reduced the duration of morning stiffness (P = 0.024), number of tender joints (P = 0.035), intensity of pain (P = 0.025) and the doctor’s scoring of rheumatic disease activity (P = 0.025) at the end of the 10-day treatment period. Analysis of the effects as area under the curve (area between the curve and baseline, zero) for the entire period from start of treatment until 6 months’ post-treatment suggested a long-lasting beneficial effect of seal oil administration on joint pain, whereas soy oil tended (not significantly) to aggravate the condition. Consistently, the serum ratios of n-6 to n-3 FAs (P 0.01) and arachidonic acid to eicosapentaenoic acid (P 0.01) were reduced after treatment with seal oil. Conclusion: The results suggest distinctive, differential prolonged effects on IBD-related joint pain of short-term duodenal administration of n-3-rich seal oil (significant improvement) and n-6-rich soy oil (tendency to exacerbation). |
| Databáze: | OpenAIRE |
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