Hair cortisol concentration in anxiety disorders: exploration of relationships with symptom severity and inflammatory markers
| Autor: | Laurie C. K. Lau, Hesham Y. Elnazer, Hugo Amaro, David S. Baldwin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Hypothalamo-Hypophyseal System Hydrocortisone Pituitary-Adrenal System Gastroenterology Severity of Illness Index Rating scale Internal medicine medicine Humans Biological Psychiatry Inflammation Psychiatric Status Rating Scales Cyclooxygenase 2 Inhibitors business.industry Tumor Necrosis Factor-alpha Symptom severity Middle Aged Anxiety Disorders Interleukin-12 Antidepressive Agents Peripheral Psychiatry and Mental health Case-Control Studies Celecoxib Antidepressant Anxiety Cytokines Interleukin-2 Drug Therapy Combination Female medicine.symptom business Biomarkers medicine.drug Psychopathology Hair |
| Zdroj: | Acta neuropsychiatrica. 33(2) |
| ISSN: | 1601-5215 0924-2708 |
| Popis: | Background:Hair cortisol concentration (HCC) can be used to periodically assess hypothalamic–pituitary–adrenal (HPA) axis function, and appears correlated with prolonged exposure to stress.Methods:Serial assessment (at Baseline, Week 6 and Week 12) of participants (n = 35) with anxiety disorders by psychopathological rating scales, with assays of HCC and levels of peripheral anti- and pro-inflammatory cytokines. Patients underwent antidepressant treatment for an initial 6 weeks, followed by cyclo-oxygenase inhibitor-2 (COX-2) inhibitor (celecoxib) augmentation or ‘treatment as usual’ for a further 6 weeks.Results:At Baseline (n = 35), HCC was elevated in patients with single-episode but not recurrent-episode anxiety disorders, mean IL-12p70 levels were low, and mean TNF-α levels were elevated. Following 6 weeks of antidepressant treatment (n = 33), mean HCC was within the normal range but mean IL-2 level was low. Celecoxib augmentation (n = 18) was associated with a reduction in anxiety symptoms and normalisation of mean IL-2 levels.Limitations:Small sample size. Not all participants were assessed at all time points.Conclusion:Serial assessment of HCC is practicable in patients with anxiety disorders. These preliminary findings warrant further investigation in larger samples. |
| Databáze: | OpenAIRE |
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