Prognostic Factors in Malignant Gliomas with Special Reference to Intra-Arterial Chemotherapy
| Autor: | Henry Hirschberg, E. Hannisdal, Bjarne Hager, Kjell Watne, O. Nome |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Oncology Vincristine medicine.medical_specialty Pathology medicine.medical_treatment Procarbazine Central nervous system disease Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Infusions Intra-Arterial Radiology Nuclear Medicine and imaging Retrospective Studies Carmustine Chemotherapy Performance status Brain Neoplasms business.industry Glioma Hematology General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Frontal lobe Chemotherapy Adjuvant Female business medicine.drug Anaplastic astrocytoma |
| Zdroj: | Acta Oncologica. 32:307-310 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.3109/02841869309093600 |
| Popis: | Survival was analyzed in 173 patients with malignant gliomas to study the importance of possible pretreatment prognostic factors. Seventy-nine of these patients received preirradiation intra-arterial chemotherapy with BCNU combined with vincristine intravenously and procarbazine orally; the others received only postoperative whole-brain irradiation. To judge by univariate and multivariate analyses the most important pretreatment prognostic factors were histology, corticosteroid dependency, pretreatment performance status and frontal lobe location of the tumors. Patients with anaplastic astrocytoma, not corticosteroid-dependent, with pretreatment performance status of 0-2 and with a frontal lobe location of the tumor seemed to benefit most from preirradiation chemotherapy. |
| Databáze: | OpenAIRE |
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