Catalytic Asymmetric Thiofunctionalization of Unactivated Alkenes
| Autor: | Thomas Vogler, David J. P. Kornfilt, Scott E. Denmark |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
Double bond Intermolecular force chemistry.chemical_element Stereoisomerism Phosphoramides General Chemistry Alkenes Amides Biochemistry Sulfur Article Catalysis Substrate Specificity Colloid and Surface Chemistry chemistry Nucleophile Electrophile Organic chemistry Phosphoric Acids |
| Zdroj: | Journal of the American Chemical Society. 133:15308-15311 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja2064395 |
| Popis: | Catalytic asymmetric sulfenylation of double bonds has been achieved using a BINAM-based phosphoramide catalyst and an electrophilic sulfur source. Simple alkenes as well as styrenes afforded sulfenylated tetrahydrofurans and tetrahydropyrans by closure with pendant hydroxyl or carboxyl groups. Intermolecular thiofunctionalizations were also achieved with simple alcohols or carboxylic acids as the nucleophiles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|