Changes in thymus volume in adult HIV-infected patients under HAART: correlation with the T-cell repopulation
| Autor: | Amalia Rubio, Miguel C. Leal, Jaime M. Franco, Ezequiel Ruiz-Mateos, Manuel Martinez-Moya, Elena Merchante, Armando Sánchez-Quijano, Eduardo Lissen |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_treatment T cell Immunology Spleen HIV Infections Thymus Gland T-Lymphocyte Subsets Immunopathology Antiretroviral Therapy Highly Active Clinical Studies medicine Immunology and Allergy Humans Sida Chemotherapy biology business.industry Age Factors virus diseases T lymphocyte Organ Size Viral Load biology.organism_classification CD4 Lymphocyte Count medicine.anatomical_structure HIV-1 Female Viral disease business Tomography X-Ray Computed Viral load |
| Zdroj: | Clinical and experimental immunology. 130(1) |
| ISSN: | 0009-9104 |
| Popis: | Summary An important thymus role has been suggested in T-cell repopulation after HAART in adult HIV-1 infected patients. Thymus volume increase after treatment has been described in HIV-1 infected children but not in adult patients. The objective of this work was to evaluate the effect of HAART on the thymic volume of adult HIV-1 infected patients and its relation with the T-cell repopulation. Twenty-one adult patients following 24 weeks under HAART were included in the study. All patients underwent a thoracic computed tomography (CT) evaluation for the measurement of thymic volumes at weeks 0, 12 and 24. Baseline thymus volume showed a significant correlation with the patient's age. Thymic volume significantly increased after 24 weeks of HAART. Besides, a significant correlation between changes in the thymus volume and changes in both total and naïve CD4+ cell counts was found. Only patients with increases ≥100 CD4+ cell counts after treatment significantly increased the thymic volume. These data show the first evidence of an early change in thymic volume of adult HIV-1 infected patients under HAART. This increase was related to the rise of both total and naïve CD4+ cell counts suggesting a functional role of thymic volume increase. |
| Databáze: | OpenAIRE |
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