Peripheral blood and portal tract lymphocyte populations in primary sclerosing cholangitis
| Autor: | Kenneth A. Fleming, J A Snook, G K Sachdev, A. Heryet, Roger W. Chapman, Derek P. Jewell, P.M.A. Kelly |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Antigens Differentiation T-Lymphocyte CD4-Positive T-Lymphocytes Male medicine.medical_specialty Pathology Adolescent Biopsy T-Lymphocytes Lymphocyte T cell Cholangitis Sclerosing digestive system Gastroenterology Primary sclerosing cholangitis Immunoenzyme Techniques Pathogenesis Primary biliary cirrhosis Crohn Disease Internal medicine medicine Humans Serum Albumin Aged Hepatology Liver Cirrhosis Biliary business.industry Bilirubin T lymphocyte Middle Aged Alkaline Phosphatase medicine.disease Ulcerative colitis digestive system diseases Portal System medicine.anatomical_structure Colitis Ulcerative Female business CD8 |
| DOI: | 10.1016/0168-8278(89)90073-1 |
| Popis: | The relative distribution of lymphocyte subpopulations in the blood and liver of patients with primary sclerosing cholangitis (PSC) and related diseases has been studied using immunoenzyme techniques. The peripheral blood CD4/CD8 T lymphocyte ratio was significantly higher in active ulcerative colitis (UC) and in PSC with inactive UC than in inactive UC alone. In contrast, no relationship with disease activity was seen in Crohn's disease. The portal tract t lymphocyte count per high power field (mean +/- S.D.) was higher in pre-cirrhotic PSC (173 +/- 105) and primary biliary cirrhosis (PBC: 210 +/- 110) than in histologically normal liver (42 +/- 27). However, the overall portal tract CD4/CD8 ratio was similar in PSC (1.49), PBC (1.89) and normal controls (1.63). The results are consistent with immunological involvement in the pathogenesis of PSC, but argue against the hypothesis that changes in the peripheral blood T cell subsets are due to sequestration at the site of tissue inflammation. |
| Databáze: | OpenAIRE |
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