The complex-in-a-complex cation [Pt(acac)2⊂(p-cym)6Ru6(tpt)2(dhnq)3]6+: Its stability towards biological ligands
Autor: | Lydia E. H. Paul, Julien Furrer, Bruno Therrien |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
chemistry.chemical_classification
010405 organic chemistry Chemistry Stereochemistry 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Amino acid Inorganic Chemistry 540 Chemistry Materials Chemistry 570 Life sciences biology Nucleotide Physical and Theoretical Chemistry Double stranded Human proteins |
DOI: | 10.7892/boris.105244 |
Popis: | The reactivity of the highly cytotoxic complex-in-a-complex cation [Pt(acac)2⊂(p-cym)6Ru6(tpt)2(dhnq)3]6+ ([Pt(acac)2⊂1]6+) towards amino acids, proteins, nucleotides and an oligonucleotide was investigated by NMR, MS, UV/Vis and CD experiments. The similarities and differences between the metallaprism [Pt(acac)2⊂1]6+, its empty counterpart [1]6+ and the previously reported smaller complex-in-a-complex cation [Pt(acac)2⊂(p-cym)6Ru6(tpt)2(dhbq)3]6+ ([Pt(acac)2⊂2]6+) were described. The reactivity of [Pt(acac)2⊂1]6+ towards amino acids and the degradation products formed were similar to those observed with [1]6+ and [Pt(acac)2⊂2]6+ but the kinetic of the reactions was much slower. Interestingly, [Pt(acac)2⊂1]6+ imposed stronger structural effects on the human proteins HsA, Tf, Mb, Cyt c, and Ub compared to the empty metallaprism [1]6+. The effects were similar to those of [Pt(acac)2⊂2]6+. Unlike [Pt(acac)2⊂2]6+ and as observed previously with [1]6+, [Pt(acac)2⊂1]6+ did not react with nucleotides. However, similar interactions with a double stranded oligonucleotide were observed in the presence of both metallaprisms [Pt(acac)2⊂1]6+ and [1]6+. In solution, [Pt(acac)2⊂1]6+ disassembles at a lower rate than [Pt(acac)2⊂2]6+. Overall, the results show that the enhanced stability of [1]6+ is kept when a guest is trapped inside the hydrophobic cavity, suggesting that the half-life of [Pt(acac)2⊂1]6+ in the blood is probably sufficiently long to enter cells and reach the target intact. |
Databáze: | OpenAIRE |
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