Bone metabolism dynamics in the early post-transplant period following kidney and liver transplantation

Autor:	Schreiber, Peter W, Bischoff-Ferrari, Heike A, Boggian, Katia, Bonani, Marco, van Delden, Christian, Enriquez, Natalia, Fehr, Thomas, Garzoni, Christian, Hirsch, Hans H, Hirzel, Cédric, Manuel, Oriol, Meylan, Pascal, Saleh, Lanja, Weisser, Maja, Mueller, Nicolas J, Swiss Transplant Cohort Study
Přispěvatelé:	Swiss Transplant Cohort Study (STCS), University of Zurich, Mueller, Nicolas J
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Male Critical Care and Emergency Medicine 11221 Clinic for Geriatric Medicine medicine.medical_treatment Organic chemistry Parathyroid hormone Liver transplantation Biochemistry Gastroenterology Fractures Bone 0302 clinical medicine Phosphates/blood Medicine Prospective Studies 610 Medicine & health lcsh:Science 10038 Institute of Clinical Chemistry ddc:616 ddc:617 Kidney Transplantation/adverse effects Vitamins Physical sciences Nutritional deficiencies Parathyroid Hormone Bone Remodeling Traumatic Injury Procollagen medicine.medical_specialty Surgical and Invasive Medical Procedures 1100 General Agricultural and Biological Sciences Bone and Bones Urinary System Procedures vitamin D deficiency Digestive System Procedures 03 medical and health sciences 1300 General Biochemistry Genetics and Molecular Biology Vitamin D and neurology Humans 1000 Multidisciplinary Vitamin D deficiency lcsh:R Biology and Life Sciences Organ Transplantation medicine.disease Bone/etiology Peptide Fragments Hormones 030104 developmental biology Parathyroid Hormone/blood lcsh:Q Peptides Biomarkers 0301 basic medicine Procollagen/blood Peptides/blood Vitamin D/analogs & derivatives/blood lcsh:Medicine Liver Transplantation/adverse effects Bone remodeling 10234 Clinic for Infectious Diseases Bone Density Medicine and Health Sciences Renal Transplantation 10035 Clinic for Nephrology 030212 general & internal medicine Vitamin D Trauma Medicine Kidney transplantation Kidney Multidisciplinary Middle Aged Bone Remodeling/physiology Chemistry medicine.anatomical_structure Bone Fracture Female Anatomy Research Article Glomerular Filtration Rate Adult Collagen Type I/blood Bone and Bones/metabolism Collagen Type I Phosphates Chemical compounds Internal medicine Organic compounds Nutrition Transplantation business.industry Kidneys Renal System Kidney Transplantation Liver Transplantation Biomarkers/blood Fractures Bone/etiology Peptide Fragments/blood Vitamin D/analogs & derivatives Vitamin D/blood business Fractures
Zdroj:	PLoS ONE, Vol 13, Iss 1, p e0191167 (2018) PloS one, vol. 13, no. 1, pp. e0191167 PLOS ONE, Vol. 13, No 1 (2018) P. e0191167 PLoS ONE Schreiber, Peter W; Bischoff-Ferrari, Heike A; Boggian, Katia; Bonani, Marco; van Delden, Christian; Enriquez, Natalia; Fehr, Thomas; Garzoni, Christian; Hirsch, Hans H; Hirzel, Cédric; Manuel, Oriol; Meylan, Pascal; Saleh, Lanja; Weisser, Maja; Mueller, Nicolas J (2018). Bone metabolism dynamics in the early post-transplant period following kidney and liver transplantation. PLoS ONE, 13(1), e0191167. Public Library of Science 10.1371/journal.pone.0191167
ISSN:	1932-6203
DOI:	10.1371/journal.pone.0191167
Popis:	Bone disease contributes to relevant morbidity after solid organ transplantation. Vitamin D has a crucial role for bone metabolism. Activation of vitamin D depends on the endocrine function of both, liver and kidney. Our study assessed key markers of bone metabolism at time of transplantation and 6 months after transplantation among 70 kidney and 70 liver recipients. In 70 kidney recipients 25-OH vitamin D levels did not differ significantly between peri-transplant (median 32.5nmol/l) and 6 months post-transplant (median 41.9nmol/l; P = 0.272). Six months post-transplant median 1, 25-(OH)2 vitamin D levels increased by >300% (from 9.1 to 36.5ng/l; P
Databáze:	OpenAIRE
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