Comment on 'Fibroblasts in Nodular Sclerosing Classical Hodgkin Lymphoma Are Defined by a Specific Phenotype and Protect Tumor Cells from Brentuximab-Vedotin Induced Injury' Cancers 2019, 11, 1687

Autor:	Donatella Aldinucci, Alfonso Colombatti
Rok vydání:	2020
Předmět:	0301 basic medicine Cancer Research lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Nodular sclerosis hemic and lymphatic diseases Gene expression Medicine Cytotoxic T cell Brentuximab vedotin Fibroblast Lymph node business.industry Comment Methylation Tissue inhibitor of metalloproteinase lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease n/a 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research business medicine.drug
Zdroj:	Cancers Cancers, Vol 12, Iss 2, p 343 (2020)
ISSN:	2072-6694
Popis:	We read with great interest the recent publication by Bankov et al. where they described the characteristics and functional activity of fibroblasts in Nodular Sclerosis (NS) Classical Hodgkin Lymphoma (cHL) [1]. The authors compared the gene expression and methylation profiles of fibroblasts isolated from primary lymph node suspensions and from lymphadenitis, founding significant differences, including a down regulation of the IL-7R gene and a strong up regulation of tissue inhibitor of metalloproteinase 3 (TIMP3). The authors reported that conditioned medium from Hodgkin and Reed Sternberg (HRS) tumor cells increased NS cHL fibroblast proliferation and that tumor cells were protected against the cytotoxic effects of Brentuximab-Vedotin by cHLfibroblasts [1]. [...].
Databáze:	OpenAIRE
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