Visible light promoted photoredox C(sp3)–H bond functionalization of tetrahydroisoquinolines in flow
| Autor: | Ana Filipović, Dana Vasiljević-Radović, Bojan P. Bondžić, Zdravko Džambaski |
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| Rok vydání: | 2021 |
| Předmět: |
Light
Copper catalyzed Functionalizations 010402 general chemistry 01 natural sciences Biochemistry Catalysis Alkynylations Tetrahydroisoquinolines Physical and Theoretical Chemistry Micro reactor Mannich reaction Organocatalysis 010405 organic chemistry Hydrogen bond Chemistry Organic Chemistry Photoredox catalysis Combinatorial chemistry 0104 chemical sciences Overall reactions Alkynylation Surface modification Microreactor Visible spectrum |
| Zdroj: | Organic and Biomolecular Chemistry |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/d0ob02582h |
| Popis: | A merger of organocatalysis and visible light photoredox catalysis performed in flow allowed access to a wide range of functionalizedN-aryl-substituted tetrahydroisoquinolines (THIQs) in a formal C-H oxidation/Mannich reaction. Strecker type functionalization and copper-catalyzed alkynylation of severalN-aryl-substituted THIQs were also successfully performed in flow, giving valuable products with high efficiencies. The use of custom-made porous polymeric type microreactors proved to be crucial regarding the C-H oxidation step and overall reaction performance. Supplementary material: [https://cer.ihtm.bg.ac.rs/handle/123456789/4495] |
| Databáze: | OpenAIRE |
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