Circulating miR-499a and miR-125b as Potential Predictors of Left Ventricular Ejection Fraction Improvement after Cardiac Resynchronization Therapy
Autor: | Isabel Moscoso, María Cebro-Márquez, Álvaro Martínez-Gómez, Charigan Abou-Jokh, María Amparo Martínez-Monzonís, José Luis Martínez-Sande, Laila González-Melchor, Javier García-Seara, Xesús Alberte Fernández-López, Sandra Moraña-Fernández, José R. González-Juanatey, Moisés Rodríguez-Mañero, Ricardo Lage |
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Jazyk: | angličtina |
Rok vydání: | 2022 |
Předmět: |
Male
QH301-705.5 Gene Expression Profiling Heart Ventricles heart failure cardiac resynchronization therapy Stroke Volume General Medicine cardiac biomarker Models Biological Article microRNAs adverse remodelling Electrocardiography Gene Expression Regulation Predictive Value of Tests cardiac therapeutic target Humans Female Biology (General) Aged |
Zdroj: | Cells, Vol 11, Iss 271, p 271 (2022) Cells Cells; Volume 11; Issue 2; Pages: 271 |
ISSN: | 2073-4409 |
Popis: | Cardiac resynchronization therapy represents a therapeutic option for heart failure drug-refractory patients. However, due to the lack of success in 30% of the cases, there is a demand for an in-depth analysis of individual heterogeneity. In this study, we aimed to evaluate the prognostic value of circulating miRNA differences. Responder patients were defined by a composite endpoint of the presence of left ventricular reverse remodelling (a reduction ≥15% in telesystolic volume and an increment ≥10% in left ventricular ejection fraction). Circulating miRNAs signature was analysed at the time of the procedure and at a 6-month follow-up. An expression analysis showed, both at baseline and at follow-up, differences between responders and non-responders. Responders presented lower baseline expressions of miR-499, and at follow-up, downregulation of miR-125b-5p, both associated with a significant improvement in left ventricular ejection fraction. The miRNA profile differences showed a marked sensitivity to distinguish between responders and non-responders. Our data suggest that miRNA differences might contribute to prognostic stratification of patients undergoing cardiac resynchronization therapy and suggest that preimplant cardiac context as well as remodelling response are key to therapeutic success. |
Databáze: | OpenAIRE |
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