Interpersonal-level discrimination indices, sociodemographic factors, and telomere length in African-Americans and Whites
| Autor: | Taylor M. Darden, Alan B. Zonderman, Leslie I. Katzel, Jason J. Ashe, Nan-ping Weng, Daniel K. Leibel, Hans B. Liu, Shari R. Waldstein, Danielle L. Beatty Moody, Michele K. Evans |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Waist Urban Population Substance-Related Disorders media_common.quotation_subject Racism 050105 experimental psychology Article White People 03 medical and health sciences Race (biology) 0302 clinical medicine Sex Factors Risk Factors Medicine Humans 0501 psychology and cognitive sciences Attrition Socioeconomic status Cellular Senescence media_common Social stress business.industry Depression General Neuroscience 05 social sciences Age Factors Middle Aged Telomere medicine.disease Health equity Black or African American Neuropsychology and Physiological Psychology Cross-Sectional Studies Social Class Regression Analysis Female Self Report business 030217 neurology & neurosurgery Demography Diversity (politics) |
| Popis: | Objective Studies have linked self-reported discrimination to telomere attrition, a biological marker of accelerated cellular aging. However, it is unknown whether intersections between social categories—race, socioeconomic status (SES), sex, and age—influence the association of varying forms of discrimination with telomere length. We examined these associations in a socioeconomically and racially/ethnically diverse urban sample. Methods Cross-sectional data were from 341 middle-aged (30–64 years) African American and White, community participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span Study (HANDLS). Multiple regression models examined up to 3-way interactions between a discrimination measure (i.e., everyday, racial, gender, lifetime burden, and frequency of discrimination across sources) and two social categories. Results After adjusting for depressive symptoms, waist circumference, and lifetime substance use, two themes emerged: 1) among women with higher SES, a) greater lifetime discrimination burden (b = -0.23, p = .011), gender discrimination (b = -0.29, p = .040), and racial discrimination (b = -0.24, p = 0.023) and 2) among younger adults, irrespective of race and sex, greater frequency of discrimination across sources (b = 0.002, p = .008) was associated with shorter telomeres. Conclusions Irrespective of race, women with higher SES and younger adults reporting greater discrimination may be at particular risk for accelerated aging. Telomere attrition promotes and accelerates chronic health conditions for which there are health disparities. Future research explicating intersections among specific discrimination indices and social categories is warranted. |
| Databáze: | OpenAIRE |
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