Targeting neuropilin-1 interactions is a promising anti-tumor strategy
| Autor: | Shao-Dan Liu, Li-Ping Zhong, Jian He, Yong-Xiang Zhao, Li-Shao Guo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Vascular Endothelial Growth Factor A
Neuropilins Endothelium lcsh:Medicine Review Article medicine.disease_cause Anti-tumor 03 medical and health sciences 0302 clinical medicine Neoplasms Neuropilin 1 medicine Humans Receptor Neovascularization Pathologic business.industry lcsh:R General Medicine Vascular Endothelial Growth Factor Family Neuropilin-1 Oncolytic virus Tumor targeting medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research Immunotherapy Carcinogenesis business 030217 neurology & neurosurgery Transforming growth factor |
| Zdroj: | Chinese Medical Journal Chinese Medical Journal, Vol 134, Iss 5, Pp 508-517 (2021) |
| ISSN: | 2542-5641 0366-6999 |
| DOI: | 10.1097/cm9.0000000000001200 |
| Popis: | Neuropilins (NRP1 and NRP2) are multifunctional receptor proteins that are involved in nerve, blood vessel, and tumor development. NRP1 was first found to be expressed in neurons, but subsequent studies have demonstrated its surface expression in cells from the endothelium and lymph nodes. NRP1 has been demonstrated to be involved in the occurrence and development of a variety of cancers. NRP1 interacts with various cytokines, such as vascular endothelial growth factor family and its receptor and transforming growth factor β1 and its receptor, to affect tumor angiogenesis, tumor proliferation, and migration. In addition, NRP1+ regulatory T cells (Tregs) play an inhibitory role in tumor immunity. High numbers of NRP1+ Tregs were associated with cancer prognosis. Targeting NRP1 has shown promise, and antagonists against NRP1 have had therapeutic efficacy in preliminary clinical studies. NRP1 treatment modalities using nanomaterials, targeted drugs, oncolytic viruses, and radio-chemotherapy have gradually been developed. Hence, we reviewed the use of NRP1 in the context of tumorigenesis, progression, and treatment. |
| Databáze: | OpenAIRE |
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