Impact of lymph node ratio on survival in stage IIIC endometrioid endometrial cancer: a Turkish Gynecologic Oncology Group study
| Autor: | Zeliha Firat Cuylan, Ali Haberal, Nazlı Topfedaisi Özkan, Tayfun Güngör, Ozgur Akbayir, Gunsu Kimyon Comert, Ali Ayhan, Hanifi Şahin, Murat Oz, Osman Turkmen, Murat Dede, Baki Erdem, Ahmet Taner Turan, Gonca Çoban, Mehmet Mutlu Meydanli, Husnu Celik, Macit Arvas |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Turkey Kaplan-Meier Estimate Gynecologic oncology Gastroenterology Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Uterine Corpus Internal medicine medicine Humans Stage IIIC Stage (cooking) Lymph node Survival rate Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Aged 80 and over 030219 obstetrics & reproductive medicine business.industry Proportional hazards model Endometrial cancer Hazard ratio Obstetrics and Gynecology General Medicine Middle Aged medicine.disease Endometrial Neoplasms Survival Rate medicine.anatomical_structure Oncology Endometrioid Carcinoma Lymphatic Metastasis 030220 oncology & carcinogenesis Lymph Node Excision Original Article Female Lymph Nodes business Carcinoma Endometrioid |
| Zdroj: | Journal of Gynecologic Oncology |
| ISSN: | 2005-0399 2005-0380 |
| Popis: | Objective: The purpose of this study was to investigate the prognostic value of lymph node ratio (LNR) in women with stage IIIC endometrioid endometrial cancer (EC). Methods: A multicenter, retrospective department database review was performed to identify patients with stage IIIC pure endometrioid EC at 6 gynecologic oncology centers in Turkey. A total of 207 women were included. LNR, defined as the percentage of positive lymph nodes (LNs) to total nodes recovered, was stratified into 2 groups: LNR1 ( 0.15). Kaplan-Meier method was used to generate survival data. Factors predictive of outcome were analyzed using Cox proportional hazards models. Results: One hundred and one (48.8%) were classified as stage IIIC1 and 106 (51.2%) as stage IIIC2. The median age at diagnosis was 58 (range, 30-82) and the median duration of follow-up was 40 months (range, 1-228 months). There were 167 (80.7%) women with LNR 0.15. The 5-year progression-free survival (PFS) rates for LNR 0.15 were 76.1%, and 58.5%, respectively (p= 0.045). An increased LNR was associated with a decrease in 5-year overall survival (OS) from 87.0% for LNR 0.15 (p= 0.005). LNR > 0.15 was found to be an independent prognostic factor for both PFS (hazard ratio [HR]= 2.05; 95% confidence interval [CI]= 1.07-3.93; p= 0.03) and OS (HR= 3.35; 95% CI= 1.57-7.19; p= 0.002). Conclusion: LNR seems to be an independent prognostic factor for decreased PFS and OS in stage IIIC pure endometrioid EC. |
| Databáze: | OpenAIRE |
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