Fear conditioning induces associative long-term potentiation in the amygdala
| Autor: | Ursula Staubli, Joseph E. LeDoux, Michael T. Rogan |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Fear processing in the brain
Multidisciplinary musculoskeletal neural and ocular physiology Conditioning Classical Long-Term Potentiation Association Learning Classical conditioning Long-term potentiation Fear Biology Amygdala Rats medicine.anatomical_structure nervous system Memory Neuroplasticity Evoked Potentials Auditory LTP induction medicine Animals Memory consolidation Fear conditioning Neuroscience |
| Zdroj: | Nature. 390:604-607 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/37601 |
| Popis: | Long-term potentiation (LTP) is an experience-dependent form of neural plasticity believed to involve mechanisms that underlie memory formation. LTP has been studied most extensively in the hippocampus, but the relation between hippocampal LTP and memory has been difficult to establish. Here we explore the relation between LTP and memory in fear conditioning, an amygdala-dependent form of learning in which an innocuous conditioned stimulus (CS) elicits fear responses after being associatively paired with an aversive unconditioned stimulus (US). We have previously shown that LTP induction in pathways that transmit auditory CS information to the lateral nucleus of the amygdala (LA) increases auditory-evoked field potentials in this nucleus. Now we show that fear conditioning alters auditory CS-evoked responses in LA in the same way as LTP induction. The changes parallel the acquisition of CS-elicited fear behaviour, are enduring, and do not occur if the CS and US remain unpaired. LTP-like associative processes thus occur during fear conditioning, and these may underlie the long-term associative plasticity that constitutes memory of the conditioning experience. |
| Databáze: | OpenAIRE |
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