Inflammatory Bowel Disease Drugs: A Focus on Autophagy
| Autor: | Craig Stevens, Kirsty M Hooper, Peter G. Barlow, Paul Henderson |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Anti-Inflammatory Agents Inflammation Inflammatory bowel disease Pathogenesis 03 medical and health sciences 616 Diseases Crohn Disease Gastrointestinal Agents In vivo Autophagy medicine Humans Crohn's disease Gastrointestinal agent business.industry Gastroenterology General Medicine Inflammatory Bowel Diseases medicine.disease 030104 developmental biology Health Immunology RC Internal medicine Colitis Ulcerative Autophagy drugs IBD Crohn's disease Signal transduction medicine.symptom business Signal Transduction |
| Zdroj: | Hooper, K M, Barlow, P G, Stevens, C & Henderson, P 2016, ' Inflammatory Bowel Disease Drugs : A Focus on Autophagy ', Journal of Crohn's and Colitis . https://doi.org/10.1093/ecco-jcc/jjw127 |
| ISSN: | 1876-4479 1873-9946 |
| Popis: | Inflammatory bowel disease [IBD] is characterized by chronic inflammation of the gastrointestinal tract. Medications such as corticosteroids, thiopurines, immunomodulators and biologic agents are used to induce and maintain remission; however, response to these drugs is variable and can diminish over time. Defective autophagy has been strongly linked to IBD pathogenesis, with evidence showing that enhancing autophagy may be therapeutically beneficial by regulating inflammation and clearing intestinal pathogens. It is plausible that the therapeutic effects of some IBD drugs are mediated in part through modulation of the autophagy pathway, with studies investigating a wide range of diseases and cell types demonstrating autophagy pathway regulation by these agents. This review will highlight the current evidence, both in vitro and in vivo, for the modulation of autophagy by drugs routinely used in IBD. A clearer understanding of their mechanisms of action will be invaluable to utilize these drugs in a more targeted and personalized manner in this diverse and often complex group of patients. |
| Databáze: | OpenAIRE |
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