Aspirin and statin medication decreases the risk of myocardial infarction associated with LTA and NFKBIL1 polymorphisms
| Autor: | Ari Mennander, Salla Höyssä, Md. Shaheenul Islam, Kjell Nikus, Terho Lehtimäki, Pekka J. Karhunen, Pekka Kuukasjärvi, Riikka Rontu, Matti Tarkka, Jari Laurikka |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Aspirin Statin business.industry medicine.drug_class Maternal and child health medicine.medical_treatment inhibitor of κ-b-like gene Reproductive medicine General Medicine medicine.disease lymphotoxin-α Cytokine myocardial infarction Internal medicine medicine Cardiology Medicine lipids (amino acids peptides and proteins) Lymphotoxin α Myocardial infarction business medicine.drug |
| Zdroj: | Open Medicine, Vol 1, Iss 3, Pp 237-249 (2006) |
| ISSN: | 2391-5463 |
| Popis: | Lymphotoxin-α (LTA) is a cytokine involved in inflammatory reactions. NFKBIL1 is a regulator of the NF-κB complex. The study investigated the associations of LTA 804 C>A and NFKBIL1-63 T>A polymorphisms with the use of statin and acetylsalicylic acid (ASA) treatment in relation to myocardial infarction (MI). The study population comprised of 600 Finnish individuals who underwent coronary angiography volunteering for the Angiography and Genes Study. Genotypes were detected by the TaqMan 5′ nuclease assay. We found a interaction between the LTA genotype (p=0.002) and the NFKBIL1 genotype (p=0.012) and statin treatment in relation to MI. Subjects with the LTA AA or the NFKBIL1 AA genotype were at a 2.77 (95% CI:1.22-6.24) and 2.85 (95% CI:1.22-6.66) times higher risk, respectively, of suffering an MI when compared to other genotypes among statin non-users. ASA treatment also modulated associations between LTA and NFKBIL1 genotypes and MI (p=0.015 and p=0.028 respectively). The NFKBIL1-A-LTA-A haplotype showed a 61% increase in the risk of MI compared to the NFKBIL1-T-LTA-C haplotype among statin non-users. Anti-inflammatory medication modifies the genotype-related risk of MI, suggesting that subjects with LTA and NFKBIL1 AA haplotype might especially benefit from the treatment. |
| Databáze: | OpenAIRE |
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