Chronic Kidney Disease Risk of Isolated Systolic or Diastolic Hypertension in Young Adults: A Nationwide Sample Based‐Cohort Study
| Autor: | Sang Yeob Lim, Hong Sang Choi, Soo Wan Kim, Chang Seong Kim, Kyungdo Han, Seong Kwon Ma, Eun Hui Bae, Jin-Hyung Jung, Tae Ryom Oh |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Systole Diastolic Hypertension Blood Pressure Risk Assessment isolated diastolic hypertension Young Adult Diastole Risk Factors Internal medicine Republic of Korea Humans Medicine Renal Insufficiency Chronic Young adult Original Research Retrospective Studies business.industry Age Factors medicine.disease isolated systolic hypertension Survival Rate Blood pressure High Blood Pressure Population Surveillance Hypertension Isolated systolic hypertension Disease Progression Cardiology Female Morbidity Cardiology and Cardiovascular Medicine business chronic kidney disease Follow-Up Studies Kidney disease Cohort study |
| Zdroj: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| ISSN: | 2047-9980 |
| Popis: | Background Hypertension among young adults is common. However, the effect of isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), or systolic and diastolic hypertension (SDH) among young adults on chronic kidney disease (CKD) development is unknown. Methods and Results From a nationwide health screening database, we included 3 030 884 participants aged 20 to 39 years who were not taking antihypertensives at baseline examination in 2009 to 2010. Participants were categorized as having normal blood pressure (BP), elevated BP, stage 1 IDH, stage 1 ISH, stage 1 SDH, stage 2 IDH, stage 2 ISH, and stage 2 SDH. The primary outcome was incident CKD. A total of 5853 (0.19%) CKD events occurred. With normal BP as the reference, multivariable‐adjusted hazard ratios (HRs) (95% CIs) for CKD were 1.14 (95% CI, 1.04–1.26), elevated BP; 1.19 (95% CI, 1.10–1.28), stage 1 IDH; 1.24 (95% CI, 1.08–1.42), stage 1 ISH; 1.39 (95% CI, 1.28–1.51), stage 1 SDH; 1.88 (95% CI, 1.63–2.16), stage 2 IDH; 1.84 (95% CI, 1.54–2.19), stage 2 ISH; 2.70 (95% CI, 2.44–2.98), stage 2 SDH. The HRs for CKD were attenuated in the patients who were antihypertensive and began medication within 1 year of medical checkup than in those without antihypertensives. Conclusions Among Korean young adults, those with elevated BP, stage 1 IDH, stage 1 ISH, stage 1 SDH, stage 2 IDH, stage 2 ISH, and stage 2 SDH were associated with a higher CKD risk than those with normal BP. The CKD risk in ISH and IDH groups was similar but lower than that in the SDH group. Antihypertensives attenuated the risk of CKD in young adults with hypertension. |
| Databáze: | OpenAIRE |
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