In VitroEffects of Lithium Chloride on TNFα and IL-6 Production by Monocytes from Breast Cancer Patients
| Autor: | M.E. Orlando, Mario Mesiti, E. Losi, S. Chillemi, Rosaria Alba Merendino, Adriana Arena, A.B. Capozza, F. Currò |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Breast Neoplasms Monocytes Internal medicine medicine Humans Pharmacology (medical) skin and connective tissue diseases Interleukin 6 Aged Pharmacology biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Monocyte Cancer Biological activity Middle Aged medicine.disease In vitro Infectious Diseases medicine.anatomical_structure Cytokine Endocrinology Oncology Mechanism of action Case-Control Studies biology.protein Female Tumor necrosis factor alpha medicine.symptom Lithium Chloride business |
| Zdroj: | Journal of Chemotherapy. 9:219-226 |
| ISSN: | 1973-9478 1120-009X |
| DOI: | 10.1179/joc.1997.9.3.219 |
| Popis: | It is well known that lithium chloride (LiCl) is able to trigger human monocytes to release tumor necrosis factor alpha (TNF alpha). In this study we have evaluated the in vitro effect of LiCl on TNF alpha and interleukin-6 (IL-6) release by monocytes from patients affected by non-metastatic (BCa/M0) and metastatic breast cancer (BCa/M1), preincubated with autologous serum (sPt). Our data demonstrate that monocytes from cancer patients (BCa) treated with LiCl released lower amounts of TNF alpha compared to those from healthy donors (HD). Preincubation in autologous serum (sPt) impaired TNF alpha production by monocytes from BCa with LiCl. On the contrary, our data indicate that IL-6 production by monocytes treated was not impaired. Moreover, the results obtained from the same cells, preincubated in sPt and treated with LiCl, indicate that serum factors may synergize with LiCl treatment in releasing IL-6. |
| Databáze: | OpenAIRE |
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