Comparative study of two human diploid rabies vaccines administered with antirabies globulin
| Autor: | S Smerdel, Baklaić Z, Svjetlicić M, Pierre Sureau, Mate Ljubičić, Monique Lafon, I Vodopija |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Rabies Vaccination schedule Biology medicine.disease_cause medicine Humans Neutralizing antibody Lyssavirus Duck embryo vaccine General Veterinary General Immunology and Microbiology Immune Sera Immunogenicity Rabies virus Immunization Passive Public Health Environmental and Occupational Health Middle Aged medicine.disease biology.organism_classification Diploidy Virology Drug Combinations Infectious Diseases Rabies Vaccines Immunization Immunology biology.protein Molecular Medicine |
| Zdroj: | Vaccine. 6:489-490 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/0264-410x(88)90098-9 |
| Popis: | The association of human rabies immune globulin (HRIG) to the vaccine is recommended for postexposure rabies treatment in cases of severe exposure. In a previous study using an abbreviated postexposure vaccination schedule it was observed that passive immunization could partially inhibit the active immune response, with three cell-culture purified vaccines but not with the concentrated human diploid cell vaccine (HDCV). In order to see if this difference was related to the purification process, the present study was designed comparing two HDCV, one concentrated and the other concentrated and purified, both of them administered in association with HRIG. The neutralizing antibody response in the vaccines was found to be identical with both vaccines, ruling out the role of the purification and confirming the excellent immunogenicity of both human diploid cell vaccines and the absence of inhibition of the active immune response by the association of HRIG to HDCV. |
| Databáze: | OpenAIRE |
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