Therapy against ischemic injury
| Autor: | Paola Capozza, Francesca Donati, Alda Huqi, Mario Marzilli, Giacinta Guarini, Doralisa Morrone |
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| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
medicine.medical_specialty Humans Ischemic Preconditioning Myocardial Mitochondria Reperfusion Injury business.industry Translational medicine Ischemic injury medicine.disease Surgery Clinical Practice Critical appraisal Reperfusion therapy Drug Discovery medicine Myocardial In patient Myocardial infarction Intensive care medicine business Ischemic Preconditioning Reperfusion injury |
| Zdroj: | BASE-Bielefeld Academic Search Engine |
| ISSN: | 1873-4286 |
| Popis: | The advent of reperfusion therapy constituted a historical change for the management of myocardial infarction (MI) patients. However, shortly after, experimental models recognized an intrinsic damage, related to reperfusion itself, which was termed as ischemiareperfusion injury (IRI). Clinical studies attribute IRI a significant burden of morbidity and mortality observed in patients undergoing successful epicardial reperfusion. Several mechanisms have been identified and, as many strategies, have been investigated to address the phenomenon. In this review we will discuss the current evidence for IRI, pharmacological and non-pharmacological preventive strategies adopted both in experimental models and in clinical practice. Finally, we will try to provide a critical appraisal to the lack of consistent benefit observed in translational medicine. |
| Databáze: | OpenAIRE |
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