Synthesis of the C1-C18 fragment of rhizopodin: late-state introduction of the oxazole

Autor:	Jonathan M. White, Darran A. Loits, Tobias Bender, Mark A. Rizzacasa
Rok vydání:	2014
Předmět:	The Myxobacteria Diene Molecular Structure Stereochemistry Organic Chemistry Stereoisomerism Metathesis Biochemistry Acylation chemistry.chemical_compound chemistry Fragment (logic) Rhizopodin Macrolides Myxococcales Physical and Theoretical Chemistry Oxazoles Oxazole
Zdroj:	Organic letters. 16(5)
ISSN:	1523-7052
Popis:	The synthesis of the C1-C18 fragment of the myxobacteria metabolite rhizopodin is described. Initial attempts at installing the E,E-diene via cross coupling with an oxazole fragment gave poor results. An alternative approach, in which the diene was formed prior and the oxazole introduced by an acylation/O,N-shift protocol, gave the C1-C18 fragment 2 of rhizopodin (1).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be09c2534f7c4d41ac572933a199fc9 https://pubmed.ncbi.nlm.nih.gov/24524264 Zobrazit plný text záznamu