Association of COMT and TPH-2 genes with DSM-5 based PTSD symptoms
| Autor: | Armen K. Goenjian, Ernest P. Noble, Sofia T. Stepanyan, Julia N. Bailey, David P. Walling, Alan M. Steinberg, Sugandha Dandekar |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Linkage disequilibrium Adolescent Genotype Poison control Tryptophan Hydroxylase Catechol O-Methyltransferase Severity of Illness Index behavioral disciplines and activities Linkage Disequilibrium White People DSM-5 Stress Disorders Post-Traumatic Recall bias mental disorders Earthquakes medicine Humans Genetic Predisposition to Disease Allele Child Psychiatry Alleles Aged Psychiatric Status Rating Scales TPH2 Depression Beck Depression Inventory Armenia Middle Aged Tryptophan hydroxylase Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health Clinical Psychology Female Psychology Clinical psychology |
| Zdroj: | Journal of Affective Disorders. 172:472-478 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/j.jad.2014.10.034 |
| Popis: | Dopaminergic and serotonergic systems have been implicated in PTSD. The present study evaluated the association of four catechol-O-methyltransferase (COMT) gene loci, and the joint effect of COMT and tryptophan hydroxylase 2 (TPH2) genes on PTSD symptoms.Subjects included 200 Caucasian Armenian adults exposed to the 1988 Spitak earthquake from 12 multigenerational (3-5 generations) families. Instruments used included the UCLA PTSD Reaction Index based on DSM-5 criteria, and the Beck Depression Inventory.The adjusted heritabilitiy of vulnerability to DSM-5 based PTSD symptoms was 0.60 (p10(-4)). There was a significant association of the COMT allele rs4633C with total PTSD (p0.03), and D category (p0.04) (negative alterations in cognitions and mood) severity scores, but not with C category (avoidance) scores. There was no genetic correlation between C and D category severity scores. COMT allele rs4633C and the TPH-2 allele rs11178997T together accounted for 7% of the variance in PTSD severity scores (p0.001). None of the COMT alleles were associated with depression.The ratings of earthquake exposure and prior trauma may have been subject to recall bias. The findings may not be generalizable to other ethnic/racial populations.COMT allele rs4633C may be causally related and/or is in linkage disequilibrium with gene(s) that are causally related to PTSD symptoms. Carriers of these COMT and the TPH-2 alleles may be at increased risk for PTSD. The findings provide biological support for dividing DSM-IV category C symptoms into DSM-5 categories C and D. |
| Databáze: | OpenAIRE |
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