Spatially featured porous chitosan conduits with micropatterned inner wall and seamless sidewall for bridging peripheral nerve regeneration
| Autor: | Luzhong Zhang, Chengbin Xue, Yinxin Zhao, Hongkui Wang, Yumin Yang, Yang Xiaoming, Guicai Li |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Materials science Bridging (networking) Polymers and Plastics Surface Properties 02 engineering and technology Regenerative medicine Artificial Implants Chitosan Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Tissue engineering Peripheral nerve Materials Chemistry Animals Particle Size Porosity Tissue Engineering Guided Tissue Regeneration Organic Chemistry 021001 nanoscience & nanotechnology Sciatic Nerve Nerve Regeneration Rats 030104 developmental biology chemistry Sciatic nerve 0210 nano-technology Biomedical engineering |
| Zdroj: | Carbohydrate polymers. 194 |
| ISSN: | 1879-1344 |
| Popis: | In this study, a facile process for efficient and scalable fabrication of biomaterials conduits with seamless sidewall and longitudinally aligned structure on luminal inwall by combining use of lyophilization and micromolding method was firstly developed and reported. The micropatterned chitosan conduits possessed better mechanical matching with the normal sciatic nerve. The highly aligned microstructure could accelerate the orientation growth of newborn tissue, whereas the porous sidewall is anticipated to be beneficial for loading biofactors and reducing nutrition leakage or neurite exogenesis. The as prepared chitosan conduits with micropatterned inwall are proven to significantly promote the regeneration of 10 mm-gapped sciatic nerve of rat. Taken together, the study provides an important experiment and application basis for design and development of new generation of artificial implants for peripheral nerve regeneration, which may also substantially extend current knowledge concerning the engineered biomaterials conduits for tissue engineering and regenerative medicine. |
| Databáze: | OpenAIRE |
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