The risk factors for malignancy in surgically treated patients for Graves' disease, toxic multinodular goiter, and toxic adenoma

Autor: Yasemin, Senyurek Giles, Yasemin, Giles Senyurek, Faith, Tunca, Tunca, Fatih, Harika, Boztepe, Boztepe, Harika, Yersu, Kapran, Kapran, Yersu, Tarik, Terzioglu, Terzioglu, Tarik, Serdar, Tezelman, Tezelman, Serdar
Rok vydání: 2008
Předmět:
Zdroj: Surgery. 144(6)
ISSN: 1532-7361
Popis: Background The impact of age, gender, and coexisting cold nodules on the frequency of thyroid carcinoma in hyperthyroid patients in an endemic iodine-deficient region was investigated. Methods The medical records of 817 patients who underwent operations for Graves' disease (GD) ( n = 342), toxic multinodular goiter (TMG) ( n = 299), and toxic adenoma (TA) ( n = 176) between January 1988 and April 2006 were reviewed. Results Cold nodules were found in 293 (36%) of the patients, and 524 (64%) patients had no cold nodules. The incidence of thyroid carcinoma was 6.5% (53/817).The frequency of carcinoma was 3.8% in GD, 6.4% in TMG, and 12% in TA. The frequency of carcinoma in older patients (≥50 years) was significantly higher than in younger patients (10.2% vs 4.3%, P = .001). The presence of cold nodules significantly increased the frequency of carcinoma (13% vs 2.9%, P = .001). A tumor was discovered within a cold nodule in 45% of the patients with thyroid carcinoma. Conclusion Cold nodules are frequent in hyperthyroid patients in endemic iodine-deficient regions. Older patients (≥50 years) and cold nodules are significant risk factors for malignancy in patients with hyperthyroidism. Surgical treatment may be suitable for those particular patients if malignancy can not be excluded.
Databáze: OpenAIRE